Gene Page: HGF

Summary
GeneID  3082
Symbol  HGF
Synonyms  F-TCF|HGFB|HPTA|SF
Description  hepatocyte growth factor (hepapoietin A; scatter factor)
See related  HGNC:4893|MIM:142409|Ensembl:ENSG00000019991|HPRD:00799|
Locus tag  -
Gene type  protein-coding
Map location  7q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0003824catalytic activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI15167892 
GO:0008083growth factor activityNAS2531289 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIEA-
GO:0000902cell morphogenesisIEA-
GO:0001889liver developmentIEA-
GO:0001837epithelial to mesenchymal transitionTAS14679171 
GO:0006508proteolysisIEA-
GO:0007067mitosisNAS2531289 
GO:0007596blood coagulationIEA-
GO:0048012hepatocyte growth factor receptor signaling pathwayIEA-
GO:0006916anti-apoptosisIEA-
GO:0051450myoblast proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2531289 
GO:0031093platelet alpha granule lumenEXP2531289 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CLEC3BDKFZp686H17246 | TN | TNAC-type lectin domain family 3, member B-HPRD,BioGRID12694198 
HGFF-TCF | HGFB | HPTA | SFhepatocyte growth factor (hepapoietin A; scatter factor)-HPRD,BioGRID11597998 
HGFACHGFA | MGC138395 | MGC138397HGF activator-HPRD,BioGRID8631970 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)-HPRD,BioGRID1655405 
HGF interacts with Met.BIND15161915 
NRP1BDCA4 | CD304 | DKFZp686A03134 | DKFZp781F1414 | NP1 | NRP | VEGF165Rneuropilin 1NRP1 (Npn-1) interacts with HGF. This interaction was modeled on a demonstrated interaction between rat NRP1 and human HGF.BIND15695515 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1-HPRD,BioGRID11830493 
SDC2HSPG | HSPG1 | SYND2syndecan 2-HPRD,BioGRID8157651 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_IL_7_SIGNALING 119All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_DN 4629All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN 3119All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_DN 118All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
GALIE_TUMOR_ANGIOGENESIS 87All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN 6441All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN 13588All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_DN 3722All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_OLD 1310All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_4NQO_IN_WS 4026All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_OLD 3119All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_OLD 2518All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_WS 129All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_DN 2413All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
JU_AGING_TERC_TARGETS_UP 106All SZGR genes in this pathway
VALK_AML_CLUSTER_12 3020All SZGR genes in this pathway
VALK_AML_WITH_T_8_21_TRANSLOCATION 55All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3 12868All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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