Gene Page: HK3

Summary
GeneID  3101
Symbol  HK3
Synonyms  HKIII|HXK3
Description  hexokinase 3 (white cell)
See related  HGNC:4925|MIM:142570|Ensembl:ENSG00000160883|HPRD:00806|
Locus tag  -
Gene type  protein-coding
Map location  5q35.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HLA-DRB10.820.82
ISCU0.730.68
HLA-DPA10.720.79
ANXA110.720.75
CD740.720.79
HLA-DRA0.720.77
GYG10.710.77
ART30.710.62
CEBPB0.710.69
ATG70.710.69
Top 10 negatively co-expressed genes
KIAA1949-0.47-0.53
PDE9A-0.46-0.60
SH3BP2-0.46-0.58
TUBB2B-0.45-0.58
VAV2-0.45-0.47
NKIRAS2-0.45-0.44
PKN1-0.45-0.52
ZNF311-0.45-0.50
ZNF300-0.44-0.46
ZNF551-0.44-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004396hexokinase activityEXP7150652 
GO:0004396hexokinase activityIEA-
GO:0004396hexokinase activityNAS-
GO:0004190aspartic-type endopeptidase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006096glycolysisIEA-
GO:0006096glycolysisNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7150652 
GO:0016020membraneNAS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GRNGEP | GP88 | PCDGF | PEPI | PGRNgranulinHKIII interacts with granulin precursor. This interaction was modeled on a demonstrated interaction between rat HKIII and human granulin precursor.BIND11068878 
-HPRD,BioGRID11068878 
IGFBP4BP-4 | HT29-IGFBP | IBP4 | IGFBP-4insulin-like growth factor binding protein 4HKIII interacts with IGFBP-4. This interaction was modeled on a demonstrated interaction between rat HKIII and human IGFBP-4.BIND11068878 
in vitro
Two-hybrid		BioGRID11068878 
LEPFLJ94114 | OB | OBSleptinHKIII interacts with leptin. This interaction was modeled on a demonstrated interaction between rat HKIII and human leptin.BIND11068878 
-HPRD,BioGRID11068878 
PGDS-prostaglandin D2 synthase, hematopoietic-HPRD,BioGRID11068878 
PTGDSLPGDS | PDS | PGD2 | PGDS | PGDS2prostaglandin D2 synthase 21kDa (brain)HKIII amino-terminal half interacts with PGDS. This interaction was modeled on a demonstrated interaction between rat HKIII and human PGDS.BIND11068878 
ZBTB17MIZ-1 | ZNF151 | ZNF60 | pHZ-67zinc finger and BTB domain containing 17-HPRD,BioGRID11068878 
HKIII amino-terminal half interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKIII and human Miz-1.BIND11068878 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 6241All SZGR genes in this pathway
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 3423All SZGR genes in this pathway
KEGG_GALACTOSE_METABOLISM 2622All SZGR genes in this pathway
KEGG_STARCH_AND_SUCROSE_METABOLISM 5233All SZGR genes in this pathway
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 4430All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_GLUCOSE_TRANSPORT 3829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
ROSS_AML_WITH_MLL_FUSIONS 7845All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1371771831Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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