Gene Page: APOC3

Summary
GeneID  345
Symbol  APOC3
Synonyms  APOCIII|MGC150353
Description  apolipoprotein C-III
See related  HGNC:610|MIM:107720|Ensembl:ENSG00000110245|HPRD:00132|
Locus tag  -
Gene type  protein-coding
Map location  11q23.1-q23.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CST30.910.96
AC011427.10.860.93
SLC7A100.850.91
HSD17B140.840.91
METRN0.820.91
AIFM30.820.90
TSC22D40.810.90
S100A160.800.91
GATSL30.790.76
TLCD10.790.91
Top 10 negatively co-expressed genes
C6orf168-0.75-0.83
SPATS2-0.73-0.85
EIF4ENIF1-0.73-0.81
PREP-0.72-0.81
RASA1-0.72-0.79
ARIH2-0.72-0.82
TERF2-0.72-0.84
ZNF329-0.72-0.83
UBP1-0.72-0.79
ZRANB1-0.72-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005543phospholipid bindingIDA4066713 |11060345 
GO:0005319lipid transporter activityIEA-
GO:0030234enzyme regulator activityIDA11060345 
GO:0015485cholesterol bindingIC11162594 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIDA16443932 
GO:0016042lipid catabolic processIEA-
GO:0006869lipid transportIEA-
GO:0033344cholesterol effluxIDA11162594 |16443932 
GO:0051005negative regulation of lipoprotein lipase activityIDA11060345 
GO:0042157lipoprotein metabolic processIEA-
GO:0019433triacylglycerol catabolic processIDA11060345 
GO:0034375high-density lipoprotein particle remodelingIMP17438339 
GO:0032488Cdc42 protein signal transductionIDA16443932 
GO:0033700phospholipid effluxIDA11162594 
GO:0045717negative regulation of fatty acid biosynthetic processIDA11060345 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP4345202 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA11060345 
GO:0034366spherical high-density lipoprotein particleIDA17438339 
GO:0034363intermediate-density lipoprotein particleIDA17336988 
GO:0034361very-low-density lipoprotein particleIDA16935699 
GO:0042627chylomicronIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 1512All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_DN 2516All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP 7049All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway


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