Gene Page: IGF2

Summary
GeneID  3481
Symbol  IGF2
Synonyms  C11orf43|FLJ22066|FLJ44734|INSIGF|pp9974
Description  insulin-like growth factor 2 (somatomedin A)
See related  HGNC:5466|MIM:147470|Ensembl:ENSG00000167244|HPRD:00939|HPRD:17410|
Locus tag  -
Gene type  protein-coding
Map location  11p15.5
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005159insulin-like growth factor receptor bindingTAS1845984 
GO:0005158insulin receptor bindingIPI12138094 
GO:0005515protein bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001501skeletal system developmentTAS8298652 
GO:0006349genetic imprintingTAS8968759 
GO:0009887organ morphogenesisIEA-
GO:0008283cell proliferationIEA-
GO:0008286insulin receptor signaling pathwayTAS1845984 
GO:0007275multicellular organismal developmentTAS6382022 
GO:0032583regulation of gene-specific transcriptionNAS12881524 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GPC3DGSX | OCI-5 | SDYS | SGB | SGBS | SGBS1glypican 3-HPRD8589713 
IDEFLJ35968 | INSULYSINinsulin-degrading enzyme-HPRD,BioGRID1733942 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID9972281 
IGFBP1AFBP | IBP1 | IGF-BP25 | PP12 | hIGFBP-1insulin-like growth factor binding protein 1IGF-II interacts with IGFBP-1.BIND10407151 
-HPRD,BioGRID10810289 
IGFBP2IBP2 | IGF-BP53insulin-like growth factor binding protein 2, 36kDaIGF-II interacts with IGFBP-2.BIND10407151 
-HPRD,BioGRID1714916 |2465304 
|8781553 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3Reconstituted ComplexBioGRID11600567 |11749962 
IGF-II interacts with IGFBP-3.BIND10407151 
IGFBP4BP-4 | HT29-IGFBP | IBP4 | IGFBP-4insulin-like growth factor binding protein 4IGF-II interacts with IGFBP-4.BIND10407151 
-HPRD,BioGRID9722589 
IGFBP5IBP5insulin-like growth factor binding protein 5IGF-II interacts with IGFBP-5.BIND10407151 
-HPRD,BioGRID9497324 
IGFBP6IBP6insulin-like growth factor binding protein 6IGF-II interacts with IGFBP-6.BIND10407151 
-HPRD,BioGRID7683646 
IGFBP7FSTL2 | IGFBP-7 | IGFBP-7v | IGFBPRP1 | MAC25 | PSFinsulin-like growth factor binding protein 7-HPRD,BioGRID8939990 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID9722981 
NOVCCN3 | IGFBP9nephroblastoma overexpressed gene-HPRD,BioGRID10084601 
TFDKFZp781D0156 | PRO1557 | PRO2086transferrinReconstituted ComplexBioGRID11749962 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID10342887 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS 1612All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_DN 2921All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN 4933All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP 3024All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
THEODOROU_MAMMARY_TUMORIGENESIS 3124All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
LOPEZ_MBD_TARGETS_IMPRINTED_AND_X_LINKED 178All SZGR genes in this pathway
GOUYER_TATI_TARGETS_DN 1712All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
CHEN_NEUROBLASTOMA_COPY_NUMBER_GAINS 5035All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP 197110All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_UP 6140All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN 3222All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS 108All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
INGRAM_SHH_TARGETS 75All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1B 2314All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
BURTON_ADIPOGENESIS_5 12678All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP 8251All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
SEMENZA_HIF1_TARGETS 3632All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C3 3624All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_UP 3121All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
JIANG_TIP30_TARGETS_DN 2414All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_DN 5230All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a346634731A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-324-3p22072213m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-54422972303m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.