Gene Page: IL1A

Summary
GeneID  3552
Symbol  IL1A
Synonyms  IL-1A|IL1|IL1-ALPHA|IL1F1
Description  interleukin 1, alpha
See related  HGNC:5991|MIM:147760|Ensembl:ENSG00000115008|HPRD:00988|
Locus tag  -
Gene type  protein-coding
Map location  2q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS10748004 |10861041 
GO:0005149interleukin-1 receptor bindingIEA-
GO:0005515protein bindingIPI18329368 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001660feverIEA-
GO:0008285negative regulation of cell proliferationTAS3493774 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseTAS6209582 
GO:0006916anti-apoptosisTAS10748004 
GO:0006915apoptosisTAS1924307 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS1924307 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HAX1FLJ17042 | FLJ18492 | FLJ93803 | HCLSBP1 | HS1BP1 | SCN3HCLS1 associated protein X-1IL-1 NTP interacts with HAX-1.BIND11554782 
-HPRD,BioGRID11554782 
IL1AIL-1A | IL1 | IL1-ALPHA | IL1F1interleukin 1, alphaReconstituted ComplexBioGRID11554782 
IL1R2CD121b | IL1RB | MGC47725interleukin 1 receptor, type II-HPRD,BioGRID7878046 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD9820540 
NDNHsT16328 | PWCRnecdin homolog (mouse)-HPRD,BioGRID12913118 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon-HPRD10998424 
S100A13-S100 calcium binding protein A13-HPRD,BioGRID12746488 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
BIOCARTA_GRANULOCYTES_PATHWAY 149All SZGR genes in this pathway
BIOCARTA_LYM_PATHWAY 116All SZGR genes in this pathway
BIOCARTA_LAIR_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_ERYTH_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_IL10_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY 2319All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY 1511All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY 4635All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP 11466All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN 3025All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_DN 4133All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_MCF10A 4328All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_40_MCF10A 3221All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_UP 2721All SZGR genes in this pathway
ZHENG_RESPONSE_TO_ARSENITE_DN 1815All SZGR genes in this pathway
ZHANG_RESPONSE_TO_CANTHARIDIN_UP 1912All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
PAL_PRMT5_TARGETS_DN 2916All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
WORSCHECH_TUMOR_REJECTION_UP 5632All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
WILENSKY_RESPONSE_TO_DARAPLADIB 2920All SZGR genes in this pathway
GRADE_COLON_VS_RECTAL_CANCER_UP 3821All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN 12775All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_UP 5429All SZGR genes in this pathway
RAY_ALZHEIMERS_DISEASE 137All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION 12881All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_UP 8654All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-181125131m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-30-5p1291361A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-493-5p5359m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-543126132m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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