Gene Page: IL1B

Summary
GeneID  3553
Symbol  IL1B
Synonyms  IL-1|IL1-BETA|IL1F2
Description  interleukin 1, beta
See related  HGNC:5992|MIM:147720|Ensembl:ENSG00000125538|HPRD:00985|
Locus tag  -
Gene type  protein-coding
Map location  2q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS10786823 
GO:0005149interleukin-1 receptor bindingNAS1919436 
GO:0005515protein bindingIPI9062193 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIDA10748004 
GO:0001660feverIEA-
GO:0001934positive regulation of protein amino acid phosphorylationIDA10748004 
GO:0007267cell-cell signalingTAS2989698 
GO:0007165signal transductionTAS9218611 |10786823 
GO:0008285negative regulation of cell proliferationTAS3493774 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseNAS1919436 
GO:0006916anti-apoptosisIDA10748004 
GO:0006915apoptosisTAS9218611 
GO:0051091positive regulation of transcription factor activityIDA10748004 
GO:0032755positive regulation of interleukin-6 productionIEA-
GO:0019221cytokine-mediated signaling pathwayIDA10748004 
GO:0030593neutrophil chemotaxisIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0045080positive regulation of chemokine biosynthetic processIEA-
GO:0046330positive regulation of JNK cascadeIEA-
GO:0045410positive regulation of interleukin-6 biosynthetic processIEA-
GO:0045429positive regulation of nitric oxide biosynthetic processIDA8383325 
GO:0050900leukocyte migrationIEA-
GO:0050796regulation of insulin secretionIDA8383325 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS1919436 
GO:0005615extracellular spaceTAS3493774 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD9714181 
IL1R1CD121A | D2S1473 | IL-1R-alpha | IL1R | IL1RA | P80interleukin 1 receptor, type I-HPRD,BioGRID9062193 
IL1R2CD121b | IL1RB | MGC47725interleukin 1 receptor, type II-HPRD,BioGRID7878046 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD9820540 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Phenotypic SuppressionBioGRID10756100 
PRTN3ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3proteinase 3-HPRD,BioGRID10339575 
ZNF675FLJ36350 | TBZF | TIZzinc finger protein 675Phenotypic SuppressionBioGRID11751921 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
BIOCARTA_IL5_PATHWAY 109All SZGR genes in this pathway
BIOCARTA_NTHI_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
SA_MMP_CYTOKINE_CONNECTION 159All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_DN 8659All SZGR genes in this pathway
PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP 3328All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP 2313All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP 5733All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_DN 7550All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
MARKS_HDAC_TARGETS_DN 1511All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_MCF10A 4328All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_6 119All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
ONDER_CDH1_TARGETS_3_DN 5932All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN 2616All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_UP 4928All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C3 2015All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
WORSCHECH_TUMOR_REJECTION_UP 5632All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_UP 5429All SZGR genes in this pathway
CROMER_TUMORIGENESIS_UP 6336All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION 12881All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_UP 8654All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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