Gene Page: IL2

Summary
GeneID  3558
Symbol  IL2
Synonyms  IL-2|TCGF|lymphokine
Description  interleukin 2
See related  HGNC:6001|MIM:147680|Ensembl:ENSG00000109471|HPRD:00979|
Locus tag  -
Gene type  protein-coding
Map location  4q26-q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005134interleukin-2 receptor bindingTAS8476561 
GO:0005125cytokine activityIEA-
GO:0005515protein bindingIEA-
GO:0019209kinase activator activityTAS8476561 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030101natural killer cell activationTAS8476561 
GO:0007267cell-cell signalingTAS8476561 
GO:0048304positive regulation of isotype switching to IgG isotypesIEA-
GO:0008284positive regulation of cell proliferationTAS8476561 
GO:0006955immune responseTAS8476561 
GO:0006916anti-apoptosisTAS8476561 
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIEA-
GO:0051024positive regulation of immunoglobulin secretionIEA-
GO:0042104positive regulation of activated T cell proliferationIEA-
GO:0030217T cell differentiationTAS8476561 
GO:0030307positive regulation of cell growthTAS8476561 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050672negative regulation of lymphocyte proliferationIEA-
GO:0050728negative regulation of inflammatory responseIEA-
GO:0046013regulation of T cell homeostatic proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionTAS8476561 
GO:0005615extracellular spaceIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD53MOX44 | TSPAN25CD53 molecule-HPRD7963560 
DGKADAGK | DAGK1 | DGK-alpha | MGC12821 | MGC42356diacylglycerol kinase, alpha 80kDaCo-localizationBioGRID8626603 
IFNA1IFL | IFN | IFN-ALPHA | IFNA13 | IFNA@ | MGC138207 | MGC138505 | MGC138507interferon, alpha 1-HPRD,BioGRID3262520 
IL2IL-2 | TCGF | lymphokineinterleukin 2-HPRD12582206 
IL21RMGC10967 | NILRinterleukin 21 receptorAffinity Capture-WesternBioGRID11418623 
IL2RACD25 | IDDM10 | IL2R | TCGFRinterleukin 2 receptor, alphaIL2 interacts with IL2RA. This interaction was modeled on a demonstrated interaction between radiolabeled IL2 from an unspecified species and IL2RA from human.BIND2303462 
-HPRD,BioGRID1993646 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID8049354 |11035066 
IL2 interacts with IL2RB. This interaction was modeled on a demonstrated interaction between radiolabeled IL2 from an unspecified species and IL2RB from human.BIND2303462 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD,BioGRID8049354 |10662798 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory proteinKSRP interacts with IL-2 3'UTR. This interaction was modeled on a demonstrated interaction between KSRP from human and IL-2 3'UTR from an unspecified species.BIND15175153 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD10662798 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_STEM_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_TOB1_PATHWAY 2114All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
BIOCARTA_41BB_PATHWAY 1715All SZGR genes in this pathway
BIOCARTA_CTLA4_PATHWAY 2118All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY 3427All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_IL2_STAT5_PATHWAY 3023All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IL_RECEPTOR_SHC_SIGNALING 2721All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_3 2823All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_STIMULATED_UP 2919All SZGR genes in this pathway
MARSON_FOXP3_CORE_DIRECT_TARGETS 1914All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-186145151m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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