Gene Page: IL8RA

Summary
GeneID  3577
Symbol  IL8RA
Synonyms  C-C|C-C-CKR-1|CD128|CD181|CDw128a|CKR-1|CMKAR1|CXCR1|IL8R1|IL8RBA
Description  interleukin 8 receptor, alpha
See related  HGNC:6026|MIM:146929|Ensembl:ENSG00000163464|HPRD:00908|
Locus tag  -
Gene type  protein-coding
Map location  2q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004918interleukin-8 receptor activityTAS10734056 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS8381837 
GO:0006954inflammatory responseTAS10725748 
GO:0006935chemotaxisTAS10725748 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CXCL1FSP | GRO1 | GROa | MGSA | MGSA-a | NAP-3 | SCYB1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)-HPRD,BioGRID1379593 |8702798 
The amino terminus of CXCR1 interacts with MGSA. This interaction was modeled on a demonstrated interaction between rabbit CXCR1 and human MGSA.BIND15133028 
CXCL2CINC-2a | GRO2 | GROb | MGSA-b | MIP-2a | MIP2 | MIP2A | SCYB2chemokine (C-X-C motif) ligand 2-HPRD,BioGRID9260277 
CXCL3CINC-2b | GRO3 | GROg | MIP-2b | MIP2B | SCYB3chemokine (C-X-C motif) ligand 3-HPRD,BioGRID8702798 
CXCL5ENA-78 | SCYB5chemokine (C-X-C motif) ligand 5-HPRD,BioGRID8702798 |9692902 
CXCL6CKA-3 | GCP-2 | GCP2 | SCYB6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)-HPRD,BioGRID9692902 |10593335 
GNA15GNA16guanine nucleotide binding protein (G protein), alpha 15 (Gq class)-HPRD,BioGRID9843397 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD,BioGRID8662698 |8903513 
IL8CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1interleukin 8-HPRD1840701 
The amino terminus of CXCR1 interacts with IL-8. This interaction was modeled on a demonstrated interaction between rabbit CXCR1 and human IL-8.BIND15133028 
PPBPB-TG1 | Beta-TG | CTAP-III | CTAP3 | CTAPIII | CXCL7 | LA-PF4 | LDGF | MDGF | NAP-2 | PBP | SCYB7 | TC1 | TC2 | TGB | TGB1 | THBGB | THBGB1pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)-HPRD,BioGRID1427896 |8195702 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES 5727All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_UP 3019All SZGR genes in this pathway
FERRANDO_TAL1_NEIGHBORS 2115All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
MARTINELLI_IMMATURE_NEUTROPHIL_DN 139All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_DN 65All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD 2115All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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