Gene Page: ITGAL

Summary
GeneID  3683
Symbol  ITGAL
Synonyms  CD11A|LFA-1|LFA1A
Description  integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
See related  HGNC:6148|MIM:153370|Ensembl:ENSG00000005844|HPRD:01079|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF3650.930.89
KCNQ50.930.87
ARHGAP260.920.79
KCNA20.910.77
KCNH10.910.73
STXBP5L0.910.81
REPS20.910.88
LUZP10.910.77
IQSEC10.910.83
HLF0.900.80
Top 10 negatively co-expressed genes
BCL7C-0.52-0.61
AC006276.2-0.50-0.50
NME4-0.46-0.56
RPL35-0.46-0.57
C9orf46-0.46-0.47
RPLP1-0.45-0.53
RPL36-0.45-0.54
TBC1D10A-0.44-0.33
RAB13-0.44-0.56
RPL12-0.44-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0004872receptor activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12845325 |15728350 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0007155cell adhesionNAS8103515 
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0007165signal transductionNAS8103515 
GO:0006954inflammatory responseNAS8103515 
GO:0006928cell motionTAS10477596 
GO:0007159leukocyte adhesionIEA-
GO:0022409positive regulation of cell-cell adhesionIEA-
GO:0042102positive regulation of T cell proliferationIEA-
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0050798activated T cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001772immunological synapseIEASynap (GO term level: 7)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneEXP11857637 
GO:0008305integrin complexIEA-
GO:0008305integrin complexNAS8103515 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeAffinity Capture-WesternBioGRID10602019 
ESM1endocanendothelial cell-specific molecule 1Affinity Capture-WesternBioGRID11544294 
ICAM1BB2 | CD54 | P3.58intercellular adhesion molecule 1in vitro
Reconstituted Complex		BioGRID11279101 |11786177 
-HPRD10493852 |11786177 
ICAM3CD50 | CDW50 | ICAM-Rintercellular adhesion molecule 3-HPRD11353828 
ICAM5TLCN | TLNintercellular adhesion molecule 5, telencephalin-HPRD,BioGRID8995416 
ITGB2CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Affinity Capture-WesternBioGRID9442085 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, CCD11a interacts with CD45.BIND15946252 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_GRANULOCYTES_PATHWAY 149All SZGR genes in this pathway
BIOCARTA_LYM_PATHWAY 116All SZGR genes in this pathway
BIOCARTA_BLYMPHOCYTE_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_LAIR_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_MONOCYTE_PATHWAY 115All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
PID_INTEGRIN_CS_PATHWAY 2616All SZGR genes in this pathway
PID_INTEGRIN2_PATHWAY 2918All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN 6447All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_UP 4529All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_UP 6647All SZGR genes in this pathway
NUMATA_CSF3_SIGNALING_VIA_STAT3 2217All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_DN 5839All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA1_UP 10166All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway


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