Gene Page: ITGB2

Summary
GeneID  3689
Symbol  ITGB2
Synonyms  CD18|LAD|LCAMB|LFA-1|MAC-1|MF17|MFI7
Description  integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
See related  HGNC:6155|MIM:600065|Ensembl:ENSG00000160255|HPRD:02506|
Locus tag  -
Gene type  protein-coding
Map location  21q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 5.707 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SPIRE20.900.90
C7orf510.890.90
MAST10.890.90
KIFC30.890.90
ZNF512B0.880.92
ABCC100.880.88
CIC0.880.90
AC010536.20.870.89
ANO80.870.87
SNAPC40.870.90
Top 10 negatively co-expressed genes
AF347015.31-0.67-0.73
S100B-0.65-0.72
COPZ2-0.65-0.71
AC021016.1-0.64-0.76
AF347015.27-0.64-0.71
B2M-0.64-0.70
MT-CO2-0.64-0.72
PSMB9-0.64-0.69
AF347015.33-0.63-0.68
C5orf53-0.63-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005488bindingIEA-
GO:0005515protein bindingIPI12885943 
GO:0019901protein kinase bindingIPI12885943 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007160cell-matrix adhesionIEA-
GO:0007155cell adhesionIEA-
GO:0007155cell adhesionTAS1694220 
GO:0007267cell-cell signalingNAS12885943 
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0007229integrin-mediated signaling pathwayNAS12885943 
GO:0008360regulation of cell shapeNAS12885943 
GO:0006954inflammatory responseNAS12885943 
GO:0006915apoptosisNAS12885943 
GO:0007159leukocyte adhesionIDA12885943 
GO:0030593neutrophil chemotaxisIDA12885943 
GO:0050730regulation of peptidyl-tyrosine phosphorylationIDA12885943 
GO:0045123cellular extravasationIEA-
GO:0050798activated T cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP11857637 
GO:0005886plasma membraneIDA18029348 
GO:0008305integrin complexIEA-
GO:0008305integrin complexNAS12885943 
GO:0045121membrane raftIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD14-CD14 molecule-HPRD11745332 
CD226DNAM-1 | DNAM1 | PTA1 | TLiSA1CD226 molecule-HPRD,BioGRID10591186 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD10602019 
CYTH1B2-1 | CYTOHESIN-1 | D17S811E | FLJ34050 | FLJ41900 | PSCD1 | SEC7cytohesin 1-HPRD,BioGRID10835351 
Integrin beta-2 interacts with cytohesin-1.BIND9765275 
ESM1endocanendothelial cell-specific molecule 1-HPRD11544294 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2-HPRD,BioGRID10906324 
FUT4CD15 | ELFT | FCT3A | FUC-TIVfucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)-HPRD3305706 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID9442085 
HPBP | HP2-ALPHA-2 | HPA1S | MGC111141haptoglobin-HPRD11967116 
ICAM1BB2 | CD54 | P3.58intercellular adhesion molecule 1-HPRD7642561 |11279101 
in vitro
in vivo
Reconstituted Complex		BioGRID7642561 |10352278 
|11279101 
ICAM2CD102intercellular adhesion molecule 2-HPRD9786897 
ICAM3CD50 | CDW50 | ICAM-Rintercellular adhesion molecule 3-HPRD,BioGRID7822326 |11353828 
ICAM4CD242 | LWintercellular adhesion molecule 4 (Landsteiner-Wiener blood group)-HPRD10846180 
ICAM5TLCN | TLNintercellular adhesion molecule 5, telencephalin-HPRD,BioGRID8995416 
ILKDKFZp686F1765 | P59integrin-linked kinase-HPRD9736715 
ITGADADB2 | CD11D | FLJ39841integrin, alpha D-HPRD,BioGRID8777714 
ITGALCD11A | LFA-1 | LFA1Aintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Affinity Capture-WesternBioGRID9442085 
ITGAMCD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6integrin, alpha M (complement component 3 receptor 3 subunit)-HPRD,BioGRID2454931 
ITGAXCD11C | SLEB6integrin, alpha X (complement component 3 receptor 4 subunit)-HPRD,BioGRID11937543 
KNG1BDK | KNGkininogen 1-HPRD,BioGRID10845911 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptorAffinity Capture-WesternBioGRID10388537 
PRTN3ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3proteinase 3-HPRD12960243 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD8649427 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10961871 
RANBP9RANBPMRAN binding protein 9RanBPM interacts with beta-2 integrin LFA-1.BIND14722085 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseAffinity Capture-WesternBioGRID10961871 
TLN1ILWEQ | KIAA1027 | TLNtalin 1-HPRD2150484 
VNN2FOAP-4 | GPI-80vanin 2-HPRD,BioGRID12056825 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_GRANULOCYTES_PATHWAY 149All SZGR genes in this pathway
BIOCARTA_LYM_PATHWAY 116All SZGR genes in this pathway
BIOCARTA_BLYMPHOCYTE_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_LAIR_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_MONOCYTE_PATHWAY 115All SZGR genes in this pathway
BIOCARTA_TCYTOTOXIC_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_THELPER_PATHWAY 1411All SZGR genes in this pathway
PID_INTEGRIN_CS_PATHWAY 2616All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_INTEGRIN2_PATHWAY 2918All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_DN 1913All SZGR genes in this pathway
SHI_SPARC_TARGETS_DN 138All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
WANG_RESPONSE_TO_BEXAROTENE_DN 2919All SZGR genes in this pathway
FERRANDO_TAL1_NEIGHBORS 2115All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS 2513All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_DN 4127All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_4HR 5436All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
NIELSEN_GIST_AND_SYNOVIAL_SARCOMA_DN 2015All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C2 2518All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER 5542All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAMANAKA_GLIOBLASTOMA_SURVIVAL_DN 97All SZGR genes in this pathway
OKAMOTO_LIVER_CANCER_MULTICENTRIC_OCCURRENCE_UP 2515All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_DN 2013All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_2_DN 98All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_5_DN 5031All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_6 2920All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway


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