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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: EIF6

Summary

GeneID

3692

Symbol

EIF6

Synonyms

2|CAB|EIF3A|ITGB4BP|b|b(2)gcn|gcn|p27BBP

Description

eukaryotic translation initiation factor 6

Locus tag

RP4-614O4.1

Gene type

protein-coding

Map location

20q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1714

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

C3orf63

0.90

0.91

WDR44

0.90

0.91

IBTK

0.88

0.90

HERC4

0.88

0.90

ZMYND11

0.87

0.89

EDEM3

0.87

0.89

MGEA5

0.87

0.88

MORC3

0.87

0.89

DNAJC10

0.87

0.89

RABEP1

0.87

0.89

Top 10 negatively co-expressed genes

FXYD1

-0.68

-0.70

MT-CO2

-0.68

-0.72

AF347015.31

-0.67

-0.71

HIGD1B

-0.65

-0.71

ENHO

-0.65

-0.76

AF347015.21

-0.65

-0.67

AF347015.33

-0.64

-0.66

IFI27

-0.64

-0.68

AF347015.8

-0.63

-0.69

MT-CYB

-0.63

-0.67

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003743

translation initiation factor activity

IEA

GO:0005515

protein binding

IPI

15231747 |17353931

GO:0043022

ribosome binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006412

translation

IEA

GO:0042256

mature ribosome assembly

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

9374518

GO:0005638

lamin filament

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABCF1	ABC27 \| ABC50	ATP-binding cassette, sub-family F (GCN20), member 1	Two-hybrid	BioGRID	16169070
ACAP3	CENTB5 \| KIAA1716	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	Two-hybrid	BioGRID	16169070
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16169070
AKT1S1	Lobe \| MGC2865 \| PRAS40	AKT1 substrate 1 (proline-rich)	Two-hybrid	BioGRID	16169070
ALDH2	ALDH-E2 \| ALDHI \| ALDM \| MGC1806	aldehyde dehydrogenase 2 family (mitochondrial)	Two-hybrid	BioGRID	16169070
ARF6	DKFZp564M0264	ADP-ribosylation factor 6	Affinity Capture-MS	BioGRID	17353931
BCCIP	TOK-1 \| TOK1	BRCA2 and CDKN1A interacting protein	Affinity Capture-MS	BioGRID	17353931
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
C4orf27	FLJ20534 \| FLJ33423 \| FLJ42042	chromosome 4 open reading frame 27	Two-hybrid	BioGRID	16169070
CRELD1	AVSD2 \| CIRRIN \| DKFZp566D213	cysteine-rich with EGF-like domains 1	Two-hybrid	BioGRID	16169070
EIF3B	EIF3-ETA \| EIF3-P110 \| EIF3-P116 \| EIF3S9 \| MGC104664 \| MGC131875 \| PRT1	eukaryotic translation initiation factor 3, subunit B	Co-purification	BioGRID	15946946
EIF3C	EIF3S8 \| FLJ78287 \| MGC189744 \| eIF3-p110	eukaryotic translation initiation factor 3, subunit C	Co-purification	BioGRID	15946946
EIF3J	EIF3S1 \| eIF3-alpha \| eIF3-p35	eukaryotic translation initiation factor 3, subunit J	Co-purification	BioGRID	15946946
ENOX1	CNOX \| FLJ10094 \| PIG38 \| bA64J21.1 \| cCNOX	ecto-NOX disulfide-thiol exchanger 1	Two-hybrid	BioGRID	16169070
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	Affinity Capture-Western Two-hybrid	BioGRID	10906324
FIBP	FGFIBP \| FIBP-1	fibroblast growth factor (acidic) intracellular binding protein	Affinity Capture-MS	BioGRID	17353931
FUNDC2	DC44 \| FLJ33773 \| HCBP6 \| HCC3 \| MGC131676 \| MGC2495 \| PD03104	FUN14 domain containing 2	Two-hybrid	BioGRID	16169070
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	Affinity Capture-MS	BioGRID	17353931
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	Two-hybrid	BioGRID	16169070
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	-	HPRD,BioGRID	14654845
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1		eIF6 interacts with RACK1	BIND	14654845
GTPBP4	CRFG \| FLJ10686 \| FLJ10690 \| FLJ39774 \| NGB \| NOG1	GTP binding protein 4	Affinity Capture-MS	BioGRID	17353931
HAS1	HAS	hyaluronan synthase 1	Affinity Capture-MS	BioGRID	17353931
HIP1	ILWEQ \| MGC126506	huntingtin interacting protein 1	Two-hybrid	BioGRID	16169070
ITGB4	CD104	integrin, beta 4	-	HPRD,BioGRID	9374518
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
LOC387753	-	similar to 60S ribosomal protein L21	Affinity Capture-MS	BioGRID	17353931
MRPS31	IMOGN38 \| MRP-S31 \| S31mt	mitochondrial ribosomal protein S31	Two-hybrid	BioGRID	16169070
NPEPPS	MP100 \| PSA	aminopeptidase puromycin sensitive	Affinity Capture-MS	BioGRID	17353931
OAT	DKFZp781A11155 \| HOGA	ornithine aminotransferase (gyrate atrophy)	Affinity Capture-MS	BioGRID	17353931
OFD1	71-7A \| CXorf5 \| MGC117039 \| MGC117040 \| SGBS2	oral-facial-digital syndrome 1	Two-hybrid	BioGRID	16169070
PAICS	ADE2 \| ADE2H1 \| AIRC \| DKFZp781N1372 \| MGC1343 \| MGC5024 \| PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	Affinity Capture-MS	BioGRID	17353931
PDHA1	PDHA \| PDHCE1A \| PHE1A	pyruvate dehydrogenase (lipoamide) alpha 1	Two-hybrid	BioGRID	16169070
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD	14654845
PSME1	IFI5111 \| MGC8628 \| PA28A \| PA28alpha \| REGalpha	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Two-hybrid	BioGRID	16169070
RGS10	-	regulator of G-protein signaling 10	Affinity Capture-MS	BioGRID	17353931
RPL3	MGC104284 \| TARBP-B	ribosomal protein L3	Affinity Capture-MS	BioGRID	17353931
RPL34	MGC111005	ribosomal protein L34	Affinity Capture-MS	BioGRID	17353931
RPL6	SHUJUN-2 \| TAXREB107 \| TXREB1	ribosomal protein L6	Two-hybrid	BioGRID	16169070
RRP15	CGI-115 \| KIAA0507 \| MGC22291	ribosomal RNA processing 15 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
SEPT3	MGC133218 \| SEP3 \| bK250D10.3	septin 3	Two-hybrid	BioGRID	16169070
SORBS1	CAP \| DKFZp451C066 \| DKFZp586P1422 \| FLAF2 \| FLJ12406 \| KIAA1296 \| R85FL \| SH3D5 \| SH3P12 \| SORB1	sorbin and SH3 domain containing 1	Affinity Capture-MS	BioGRID	17353931
UPF3B	HUPF3B \| MRXS14 \| RENT3B \| UPF3X	UPF3 regulator of nonsense transcripts homolog B (yeast)	Two-hybrid	BioGRID	16169070
USP33	KIAA1097 \| MGC16868 \| VDU1	ubiquitin specific peptidase 33	Two-hybrid	BioGRID	16169070
WFS1	DFNA14 \| DFNA38 \| DFNA6 \| DIDMOAD \| WFRS \| WFS \| WOLFRAMIN	Wolfram syndrome 1 (wolframin)	Two-hybrid	BioGRID	16169070
YARS	CMTDIC \| TYRRS \| YRS \| YTS	tyrosyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
BIOCARTA_EIF_PATHWAY	16	9	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN	126	86	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN	77	46	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN	162	116	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP	536	340	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN	517	309	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON	31	18	All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP	197	110	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP	28	23	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR	149	84	All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN	161	105	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP	285	167	All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE	335	193	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN	146	90	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway