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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: JUP

Summary

GeneID

3728

Symbol

JUP

Synonyms

Description

junction plakoglobin

Locus tag

Gene type

protein-coding

Map location

17q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0021

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

CHST10

0.73

0.64

CTTNBP2

0.73

0.67

DAP

0.72

0.67

SLA

0.72

0.68

DOPEY2

0.72

0.67

C8orf79

0.71

0.66

POU3F2

0.71

0.60

RAI14

0.70

0.62

SEMA3C

0.70

0.67

GPR12

0.70

0.67

Top 10 negatively co-expressed genes

TNFSF12

-0.48

-0.54

SLC16A11

-0.47

-0.55

C5orf53

-0.47

-0.57

HLA-F

-0.47

-0.56

SPARCL1

-0.46

-0.57

PTH1R

-0.46

-0.55

CMTM8

-0.46

-0.52

CXCL14

-0.46

-0.65

AF347015.31

-0.45

-0.58

AF347015.27

-0.45

-0.58

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005198

structural molecule activity

IEA

GO:0008092

cytoskeletal protein binding

TAS

1639850

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007155

cell adhesion

NAS

1639850

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

IEA

GO:0005856

cytoskeleton

TAS

1639850

GO:0005624

membrane fraction

TAS

1639850

GO:0005625

soluble fraction

TAS

1639850

GO:0005737

cytoplasm

TAS

1639850

GO:0016020

membrane

IEA

GO:0030018

Z disc

IEA

GO:0005913

cell-cell adherens junction

IEA

GO:0030057

desmosome

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex	BioGRID	7651399 \|8074697
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Two-hybrid	BioGRID	16169070
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	Two-hybrid	BioGRID	16189514
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	-	HPRD,BioGRID	10803460
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD	1639850 \|8207061 \|10959047
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Reconstituted Complex	BioGRID	1639850 \|7542250 \|8074697 \|8207061 \|9535896
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD	1639850
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	Affinity Capture-MS Affinity Capture-Western	BioGRID	7650039 \|14625392
CDH3	CDHP \| HJMD \| PCAD	cadherin 3, type 1, P-cadherin (placental)	Affinity Capture-Western Co-purification	BioGRID	10910767
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	-	HPRD	9739078 \|12003790
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	Affinity Capture-Western	BioGRID	9434630 \|12003790
CTNNA1	CAP102 \| FLJ36832	catenin (cadherin-associated protein), alpha 1, 102kDa	-	HPRD,BioGRID	7650039 \|9110993
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	9535896 \|11712088
CTNNBIP1	ICAT \| MGC15093	catenin, beta interacting protein 1	Affinity Capture-MS Two-hybrid	BioGRID	16189514 \|17353931
DSC1	CDHF1 \| DG2/DG3	desmocollin 1	-	HPRD	7971964 \|9606214
DSC2	ARVD11 \| CDHF2 \| DG2 \| DGII/III \| DKFZp686I11137 \| DSC3	desmocollin 2	-	HPRD,BioGRID	9443898
DSC3	CDHF3 \| DSC \| DSC1 \| DSC2 \| DSC4 \| HT-CP	desmocollin 3	-	HPRD,BioGRID	10769211
DSG1	CDHF4 \| DG1 \| DSG	desmoglein 1	-	HPRD,BioGRID	7738346 \|9606214
DSG2	ARVC10 \| ARVD10 \| CDHF5 \| HDGC \| MGC117034 \| MGC117036 \| MGC117037	desmoglein 2	-	HPRD,BioGRID	8749329 \|10769205 \|11710948
DSG3	CDHF6 \| DKFZp686P23184 \| PVA	desmoglein 3 (pemphigus vulgaris antigen)	Affinity Capture-Western	BioGRID	7738346
DSP	DPI \| DPII	desmoplakin	-	HPRD,BioGRID	9348293
DSP	DPI \| DPII	desmoplakin	Plakoglobin interacts with desmoplakin.	BIND	12426320
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Reconstituted Complex	BioGRID	9535896
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	7702605
GJB1	CMTX \| CMTX1 \| CX32	gap junction protein, beta 1, 32kDa	Affinity Capture-Western	BioGRID	7971964
LGALS9	HUAT \| LGALS9A \| MGC117375 \| MGC125973 \| MGC125974	lectin, galactoside-binding, soluble, 9	Affinity Capture-MS	BioGRID	17353931
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	-	HPRD	9139698
MUC1	CD227 \| EMA \| H23AG \| MAM6 \| PEM \| PEMT \| PUM	mucin 1, cell surface associated	Affinity Capture-Western Co-localization	BioGRID	12939402
NFKBIE	IKBE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	Two-hybrid	BioGRID	16189514
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	Affinity Capture-Western	BioGRID	10801826
PHB2	BAP \| BCAP37 \| Bap37 \| MGC117268 \| PNAS-141 \| REA \| p22	prohibitin 2	Affinity Capture-MS	BioGRID	17353931
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11274246
PKP2	ARVD9	plakophilin 2	-	HPRD,BioGRID	11790773
PKP3	-	plakophilin 3	PKP3 interacts with JUP(Pg)	BIND	12707304
PKP3	-	plakophilin 3	Two-hybrid	BioGRID	12707304
PTPN14	MGC126803 \| PEZ \| PTP36	protein tyrosine phosphatase, non-receptor type 14	-	HPRD,BioGRID	12808048
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	-	HPRD,BioGRID	9245795
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD	12370829
PTPRK	DKFZp686C2268 \| DKFZp779N1045 \| R-PTP-kappa	protein tyrosine phosphatase, receptor type, K	-	HPRD,BioGRID	8663237
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
RIBC2	C22orf11	RIB43A domain with coiled-coils 2	Two-hybrid	BioGRID	16189514
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	-	HPRD,BioGRID	11711551
WDYHV1	C8orf32 \| FLJ10204	WDYHV motif containing 1	Two-hybrid	BioGRID	16189514

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA	60	47	All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	76	59	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY	39	33	All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY	21	19	All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY	33	32	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	27	20	All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	56	31	All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION	78	43	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP	450	256	All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP	430	232	All SZGR genes in this pathway
JAEGER_METASTASIS_DN	258	141	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_GRANULOCYTE_UP	15	9	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP	185	126	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP	55	34	All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN	133	77	All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP	316	190	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN	142	95	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	612	367	All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_DN	25	13	All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER	178	108	All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY	66	48	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA	70	38	All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN	382	224	All SZGR genes in this pathway
RICKMAN_METASTASIS_DN	261	155	All SZGR genes in this pathway
WU_CELL_MIGRATION	184	114	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS	290	172	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_NOS_TARGETS	179	105	All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA	69	47	All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN	464	276	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP	398	262	All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	66	47	All SZGR genes in this pathway
LEI_MYB_TARGETS	318	215	All SZGR genes in this pathway
CROMER_METASTASIS_DN	81	58	All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN	246	180	All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP	52	33	All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D	79	62	All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C2	25	18	All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1	58	43	All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN	25	21	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN	96	71	All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY	87	54	All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9	92	59	All SZGR genes in this pathway
KANG_CISPLATIN_RESISTANCE_UP	19	11	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_DN	24	13	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN	366	257	All SZGR genes in this pathway
MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_UP	14	10	All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP	395	249	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN	80	53	All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP	75	47	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP	430	288	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B	549	316	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN	15	10	All SZGR genes in this pathway
DURAND_STROMA_S_UP	297	194	All SZGR genes in this pathway
HECKER_IFNB1_TARGETS	95	54	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	754	760	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	754	760	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-381	1095	1101	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-9	1103	1109	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.