Gene Page: KCNMA1

Summary
GeneID  3778
Symbol  KCNMA1
Synonyms  BKTM|DKFZp686K1437|KCa1.1|MGC71881|MaxiK|SAKCA|SLO|SLO-ALPHA|SLO1|mSLO1
Description  potassium large conductance calcium-activated channel, subfamily M, alpha member 1
See related  HGNC:6284|MIM:600150|Ensembl:ENSG00000156113|HPRD:15967|
Locus tag  RP11-443A13.1
Gene type  protein-coding
Map location  10q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0003824catalytic activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI10692449 |15528406 
GO:0005244voltage-gated ion channel activityIEA-
GO:0005249voltage-gated potassium channel activityIDA7877450 |12388065 
GO:0015269calcium-activated potassium channel activityIEA-
GO:0030955potassium ion bindingIEA-
GO:0060072large conductance calcium-activated potassium channel activityIDA7993625 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionISSneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0019228regulation of action potential in neuronISSneuron (GO term level: 10)-
GO:0001666response to hypoxiaIDA15528406 
GO:0030007cellular potassium ion homeostasisIDA11245614 
GO:0048469cell maturationISS-
GO:0008152metabolic processIEA-
GO:0007628adult walking behaviorISS-
GO:0007623circadian rhythmISS-
GO:0007605sensory perception of soundISS-
GO:0007605sensory perception of soundISS-
GO:0006811ion transportIEA-
GO:0006813potassium ion transportIDA7573516 |7877450 |11245614 
|12388065 |17706472 
|18458941 
GO:0006813potassium ion transportIEA-
GO:0006970response to osmotic stressIDA10840032 |12388065 
GO:0043065positive regulation of apoptosisIMP11245614 
GO:0042391regulation of membrane potentialIDA7877450 |7993625 
GO:0050885neuromuscular process controlling balanceISS-
GO:0032344regulation of aldosterone metabolic processISS-
GO:0034465response to carbon monoxideIDA15528406 
GO:0034465response to carbon monoxideIMP18180950 
GO:0042491auditory receptor cell differentiationISS-
GO:0045794negative regulation of cell volumeIDA12388065 
GO:0046541saliva secretionISS-
GO:0060083smooth muscle contraction involved in micturitionIDA11641143 
GO:0060082eye blink reflexISS-
GO:0060087relaxation of vascular smooth muscleISS-
GO:0045475locomotor rhythmISS-
GO:0051592response to calcium ionIDA12388065 |18458941 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043195terminal buttonISSaxon, Synap, Neurotransmitter (GO term level: 8)-
GO:0045211postsynaptic membraneISSSynap, Neurotransmitter (GO term level: 5)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIDA7573516 |7877450 
GO:0009897external side of plasma membraneISS-
GO:0008076voltage-gated potassium channel complexIDA7573516 |7877450 
GO:0016324apical plasma membraneIDA10840032 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNA1HCACNA1HB | Cav3.2 | EIG6 | FLJ90484calcium channel, voltage-dependent, T type, alpha 1H subunitalpha-1-3.2 T-type calcium channel associates with BKCa potassium channel.BIND14631046 
GGT1CD224 | D22S672 | D22S732 | GGT | GTG | MGC96892 | MGC96904 | MGC96963gamma-glutamyltransferase 1-HPRD15528406 
HMOX2HO-2heme oxygenase (decycling) 2-HPRD15528406 
KCNMA1 interacts with HO-2.BIND15528406 
KCNMB1K(VCA)beta | SLO-BETA | hslo-betapotassium large conductance calcium-activated channel, subfamily M, beta member 1-HPRD8006036 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD14584897 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
DOANE_BREAST_CANCER_CLASSES_UP 7238All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_DN 7752All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
ONDER_CDH1_TARGETS_3_UP 1711All SZGR genes in this pathway
ONDER_CDH1_SIGNALING_VIA_CTNNB1 8358All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP 6644All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-138133613421Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-181121127m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-203.120272033m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/2115585641Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-224187193m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-2981198125m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-299-3p4854m8hsa-miR-299-3pUAUGUGGGAUGGUAAACCGCUU
miR-334484551A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-33881158121m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-34b785878641Ahsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-380-5p66721Ahsa-miR-380-5pUGGUUGACCAUAGAACAUGCGC
hsa-miR-563AGGUUGACAUACGUUUCCC
miR-409-3p23301A,m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-496158415901Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-543122128m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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