Gene Page: ARF6

Summary
GeneID  382
Symbol  ARF6
Synonyms  DKFZp564M0264
Description  ADP-ribosylation factor 6
See related  HGNC:659|MIM:600464|Ensembl:ENSG00000165527|HPRD:02714|
Locus tag  -
Gene type  protein-coding
Map location  14q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0192 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS1993656 
GO:0005515protein bindingIPI9312003 
GO:0005525GTP bindingTAS10913182 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001889liver developmentIEA-
GO:0007155cell adhesionTAS10036235 
GO:0006928cell motionTAS10036235 
GO:0007264small GTPase mediated signal transductionIEA-
GO:0006915apoptosisIEA-
GO:0016192vesicle-mediated transportTAS10913182 
GO:0035020regulation of Rac protein signal transductionIDA10036235 
GO:0015031protein transportIEA-
GO:0031529ruffle organizationIDA10036235 
GO:0048261negative regulation of receptor-mediated endocytosisTAS9312003 
GO:0030838positive regulation of actin filament polymerizationIMP10036235 
GO:0030866cortical actin cytoskeleton organizationIMP10913182 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIDA9312003 
GO:0005794Golgi apparatusIEA-
GO:0005622intracellularIEA-
GO:0005624membrane fractionTAS8702973 
GO:0005737cytoplasmIEA-
GO:0005768endosomeTAS10913182 
GO:0005938cell cortexIDA10913182 
GO:0005886plasma membraneIDA10036235 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunit-HPRD11926829 
AP3B1ADTB3 | ADTB3A | HPS | HPS2 | PEadaptor-related protein complex 3, beta 1 subunitReconstituted ComplexBioGRID11926829 
AP3D1ADTD | hBLVRadaptor-related protein complex 3, delta 1 subunit-HPRD11926829 
AP3S2AP3S3 | FLJ35955 | sigma3badaptor-related protein complex 3, sigma 2 subunitReconstituted ComplexBioGRID11926829 
ARFIP2POR1ADP-ribosylation factor interacting protein 2-HPRD,BioGRID9312003 
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID11533043 |11867621 
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2-HPRD,BioGRID11533043 |11867621 
ASAP2AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1ArfGAP with SH3 domain, ankyrin repeat and PH domain 2-HPRD10022920 |10749932 
CHRM3HM3cholinergic receptor, muscarinic 3-HPRD,BioGRID12799371 
CYTH2ARNO | CTS18 | CTS18.1 | PSCD2 | PSCD2L | SEC7L | Sec7p-L | Sec7p-likecytohesin 2-HPRD,BioGRID9417041 
DHPSMIG13deoxyhypusine synthaseAffinity Capture-MSBioGRID17353931 
DYNC1H1DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22dynein, cytoplasmic 1, heavy chain 1Affinity Capture-MSBioGRID17353931 
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6Affinity Capture-MSBioGRID17353931 
EPPK1EPIPL | EPIPL1epiplakin 1Affinity Capture-MSBioGRID17353931 
EXOC5DKFZp666H126 | HSEC10 | PRO1912 | SEC10 | SEC10L1 | SEC10Pexocyst complex component 5-HPRD,BioGRID14662749 
GARTAIRS | GARS | GARTF | MGC47764 | PAIS | PGFT | PRGSphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseAffinity Capture-MSBioGRID17353931 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1Affinity Capture-MSBioGRID17353931 
KIAA0368ECM29 | FLJ22036 | KIAA1962 | RP11-386D8.2KIAA0368Affinity Capture-MSBioGRID17353931 
LRPPRCCLONE-23970 | GP130 | LRP130 | LSFCleucine-rich PPR-motif containingAffinity Capture-MSBioGRID17353931 
PABPC4APP-1 | APP1 | FLJ43938 | PABP4 | iPABPpoly(A) binding protein, cytoplasmic 4 (inducible form)Affinity Capture-MSBioGRID17353931 
PIP5K1A-phosphatidylinositol-4-phosphate 5-kinase, type I, alpha-HPRD10589680 
PIP5K1CKIAA0589 | LCCS3 | PIP5K-GAMMA | PIP5Kgammaphosphatidylinositol-4-phosphate 5-kinase, type I, gamma-HPRD,BioGRID12847086 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD,BioGRID12379803 
RAB11FIP3KIAA0665 | Rab11-FIP3RAB11 family interacting protein 3 (class II)-HPRD11535061 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)Affinity Capture-WesternBioGRID12509462 
YARSCMTDIC | TYRRS | YRS | YTStyrosyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY 1514All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCIAN_INVERSED_TARGETS_OF_TP53_AND_TP73_DN 3123All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_DN 5434All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
CHEOK_RESPONSE_TO_HD_MTX_DN 2418All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
XU_CREBBP_TARGETS_DN 4431All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D4 5537All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_DN 4224All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN 1510All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_DN 2514All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1394254311Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-23577583m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-3p4854921A,m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3235775831Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-4944704761Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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