Gene Page: LBP

Summary
GeneID  3929
Symbol  LBP
Synonyms  MGC22233
Description  lipopolysaccharide binding protein
See related  HGNC:6517|MIM:151990|Ensembl:ENSG00000129988|HPRD:07175|
Locus tag  -
Gene type  protein-coding
Map location  20q11.23-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TGFBRAP10.950.95
AC097382.40.940.94
DHX370.940.95
SREBF20.940.95
NEURL40.930.95
CLIP20.930.94
DIP2C0.930.94
FOXK20.930.95
KIAA19670.930.94
BICD20.930.93
Top 10 negatively co-expressed genes
AF347015.31-0.79-0.86
MT-CO2-0.77-0.86
AF347015.27-0.76-0.84
AF347015.21-0.75-0.91
AF347015.33-0.74-0.81
AC021016.1-0.74-0.82
FXYD1-0.73-0.80
AF347015.8-0.73-0.84
MT-CYB-0.73-0.81
HIGD1B-0.73-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)2477488 
GO:0001530lipopolysaccharide bindingIEA-
GO:0008289lipid bindingIEA-
GO:0043498cell surface bindingISS2477488 
GO:0051636Gram-negative bacterial cell surface bindingIDA11528597 
GO:0051636Gram-negative bacterial cell surface bindingISS2402637 
GO:0051637Gram-positive bacterial cell surface bindingIDA12932360 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002281macrophage activation during immune responseISS2402637 
GO:0034145positive regulation of toll-like receptor 4 signaling pathwayIDA11528597 
GO:0006968cellular defense responseISS2402637 
GO:0006953acute-phase responseIEP12932360 
GO:0006953acute-phase responseISS2477488 
GO:0006869lipid transportIEA-
GO:0008228opsonizationIC12932360 
GO:0008228opsonizationISS2477488 
GO:0015920lipopolysaccharide transportIDA8985160 
GO:0032757positive regulation of interleukin-8 productionIDA8409400 
GO:0032496response to lipopolysaccharideIDA8409400 |11739189 
GO:0032490detection of molecule of bacterial originIDA11528597 
GO:0032760positive regulation of tumor necrosis factor productionIDA8409400 
GO:0032760positive regulation of tumor necrosis factor productionISS2402637 
GO:0032755positive regulation of interleukin-6 productionIDA8409400 
GO:0032720negative regulation of tumor necrosis factor productionIDA11739189 
GO:0031663lipopolysaccharide-mediated signaling pathwayIDA8409400 |11739189 
GO:0043032positive regulation of macrophage activationIDA8409400 
GO:0050830defense response to Gram-positive bacteriumIC12932360 
GO:0050830defense response to Gram-positive bacteriumIEP12932360 
GO:0050829defense response to Gram-negative bacteriumISS2402637 
GO:0045087innate immune responseIC12932360 
GO:0045087innate immune responseISS2477488 
GO:0060265positive regulation of respiratory burst during acute inflammatory responseISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP2477488 |9665271 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA2402637 |11528597 
GO:0005615extracellular spaceISS2477488 
GO:0005634nucleusIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOA1MGC117399apolipoprotein A-IAffinity Capture-WesternBioGRID8663389 
CAMPCAP18 | CRAMP | FALL-39 | FALL39 | HSD26 | LL37cathelicidin antimicrobial peptide-HPRD11544322 
CD14-CD14 molecule-HPRD,BioGRID12417309 
CFHR1CFHL | CFHL1 | CFHL1P | CFHR1P | FHR1 | H36-1 | H36-2 | HFL1 | HFL2 | MGC104329complement factor H-related 1-HPRD,BioGRID8663389 
IRF6LPS | OFC6 | PIT | PPS | VWSinterferon regulatory factor 6Reconstituted ComplexBioGRID11544322 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_UP 6841All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_UP 4629All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
CUI_TCF21_TARGETS_UP 3727All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
HAN_JNK_SINGALING_DN 3927All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
COATES_MACROPHAGE_M1_VS_M2_DN 7844All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
KAMIKUBO_MYELOID_CEBPA_NETWORK 2819All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_DN 5024All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_PROGENITOR_UP 5830All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-500162168m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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