Gene Page: SMAD9

Summary
GeneID  4093
Symbol  SMAD9
Synonyms  MADH6|MADH9|SMAD8A|SMAD8B
Description  SMAD family member 9
See related  HGNC:6774|MIM:603295|Ensembl:ENSG00000120693|
Locus tag  -
Gene type  protein-coding
Map location  13q12-q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0124 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DBNDD20.970.94
PLLP0.960.95
NINJ20.960.93
CMTM50.930.95
ELOVL10.930.92
TSPAN150.930.90
MOG0.920.95
GJB10.920.94
RNASE10.920.93
RTKN0.920.93
Top 10 negatively co-expressed genes
NKIRAS2-0.62-0.74
CRMP1-0.59-0.73
TUBB2B-0.59-0.79
KIAA1949-0.59-0.75
HN1-0.58-0.72
HMGB3-0.58-0.77
PCDHB18-0.58-0.73
YBX1-0.58-0.78
TUBB-0.58-0.73
DPYSL3-0.57-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030902hindbrain developmentIEABrain (GO term level: 8)-
GO:0030901midbrain developmentIEABrain (GO term level: 8)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007179transforming growth factor beta receptor signaling pathwayIEA-
GO:0030509BMP signaling pathwayEXP15621726 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9436979 |17356069 
GO:0005622intracellularTAS9256479 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP11121043 
GO:0005667transcription factor complexIEA-
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
SMAD4DPC4 | JIP | MADH4SMAD family member 4Affinity Capture-Western
Two-hybrid		BioGRID10583507 |16189514 
SMAD9MADH6 | MADH9 | SMAD8A | SMAD8BSMAD family member 9Affinity Capture-WesternBioGRID10583507 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1Affinity Capture-WesternBioGRID11163184 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway


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