Gene Page: MAP3K1

Summary
GeneID  4214
Symbol  MAP3K1
Synonyms  MAPKKK1|MEKK|MEKK1
Description  mitogen-activated protein kinase kinase kinase 1
See related  HGNC:6848|MIM:600982|Ensembl:ENSG00000095015|
Locus tag  -
Gene type  protein-coding
Map location  5q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0467 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CRB20.720.58
COL4A60.700.39
LRIG30.690.60
NFATC40.680.54
COL27A10.680.56
DMRTA20.680.25
DMRT30.670.41
TFAP2C0.660.30
NHLH10.660.35
ITGA20.660.51
Top 10 negatively co-expressed genes
AF347015.21-0.18-0.08
SYCP3-0.17-0.18
GNRHR-0.17-0.17
RP9P-0.17-0.27
RALYL-0.16-0.16
GNG8-0.16-0.20
KCTD9P2-0.16-0.10
AC073534.1-0.16-0.12
KLHL1-0.16-0.07
RTDR1-0.16-0.13
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIPI9808624 |11784851 |16286467 
|16636664 
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004709MAP kinase kinase kinase activityNAS9808624 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008545JUN kinase kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationNAS9808624 
GO:0007257activation of JNK activityIEA-
GO:0007179transforming growth factor beta receptor signaling pathwayIEA-
GO:0008637apoptotic mitochondrial changesIEA-
GO:0007249I-kappaB kinase/NF-kappaB cascadeEXP15276183 
GO:0042060wound healingIEA-
GO:0043010camera-type eye developmentIEA-
GO:0030838positive regulation of actin filament polymerizationIEA-
GO:0030334regulation of cell migrationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10465784 
GO:0005575cellular_componentND9808624 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AXIN1AXIN | MGC52315axin 1Affinity Capture-WesternBioGRID10829020 |11884395 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeMAP3K1 (MEKK1) interacts with the CD82 (KAI1) promoter.BIND15829968 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)Affinity Capture-MSBioGRID14743216 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Affinity Capture-WesternBioGRID10829020 
ECSITSITPECECSIT homolog (Drosophila)in vivoBioGRID10465784 
FKBP5FKBP51 | FKBP54 | MGC111006 | P54 | PPIase | Ptg-10FK506 binding protein 5Affinity Capture-MSBioGRID14743216 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID9733714 
HSP90AA2HSP90ALPHA | HSPCA | HSPCAL3heat shock protein 90kDa alpha (cytosolic), class A member 2Affinity Capture-MSBioGRID14743216 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1Affinity Capture-WesternBioGRID10969079 
MEKK1 interacts with MEK1.BIND10969079 
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4MKK4 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK4 and rat MEKK1.BIND15866172 
MEKK1 phosphorylates MEK4.BIND10969079 
MAP2K7Jnkk2 | MAPKK7 | MKK7 | PRKMK7mitogen-activated protein kinase kinase 7MEKK1 interacts with MEK7.BIND10969079 
MKK7 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK7 and rat MEKK1.BIND15866172 
MAP4K2BL44 | GCK | RAB8IPmitogen-activated protein kinase kinase kinase kinase 2Reconstituted ComplexBioGRID9712898 
GCK interacts with, and phsophorylates, MEKK1.BIND9712898 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4Affinity Capture-WesternBioGRID9135144 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Affinity Capture-WesternBioGRID10969079 
MEKK1 interacts with ERK2.BIND10969079 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3MEKK1 interacts with ERK1.BIND12049732 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID9405400 
MAPK8IP3DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2mitogen-activated protein kinase 8 interacting protein 3Affinity Capture-WesternBioGRID10523642 
PAK3CDKN1A | MRX30 | MRX47 | OPHN3 | PAK3beta | bPAK | hPAK3p21 protein (Cdc42/Rac)-activated kinase 3in vivoBioGRID9065412 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1MEKK1 interacts with Raf-1.BIND10969079 
Affinity Capture-Western
Reconstituted Complex		BioGRID10969079 
RPL30-ribosomal protein L30Affinity Capture-MSBioGRID14743216 
RPL4-ribosomal protein L4Affinity Capture-MSBioGRID14743216 
RPS13-ribosomal protein S13Affinity Capture-MSBioGRID14743216 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2Affinity Capture-Western
Co-fractionation		BioGRID10346818 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Reconstituted Complex
Two-hybrid		BioGRID9563508 
WDR68AN11 | HAN11WD repeat domain 68Affinity Capture-MSBioGRID14743216 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideReconstituted ComplexBioGRID9452471 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_CD40_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_CERAMIDE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_HCMV_PATHWAY 1716All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY 2319All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_RAC1_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_41BB_PATHWAY 1715All SZGR genes in this pathway
BIOCARTA_STRESS_PATHWAY 2518All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TNFR2_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TOLL_PATHWAY 3731All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_P38_MKK3_6PATHWAY 2621All SZGR genes in this pathway
PID_CD40_PATHWAY 3126All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_TRAIL_PATHWAY 2820All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 2117All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
WU_HBX_TARGETS_2_DN 1611All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
WU_HBX_TARGETS_1_DN 2314All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP 2014All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


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