Gene Page: MLH1

Summary
GeneID  4292
Symbol  MLH1
Synonyms  COCA2|FCC2|HNPCC|HNPCC2|MGC5172|hMLH1
Description  mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
See related  HGNC:7127|MIM:120436|Ensembl:ENSG00000076242|HPRD:00390|
Locus tag  -
Gene type  protein-coding
Map location  3p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
S100A90.680.42
S100A80.660.41
S100A120.660.40
FCN10.550.32
LYZ0.530.25
VNN20.530.30
SLC11A10.500.36
MT1A0.490.17
RNASE20.480.17
CEBPD0.480.26
Top 10 negatively co-expressed genes
AL031003.1-0.29-0.25
FAM98A-0.28-0.24
PITPNB-0.27-0.26
KATNAL1-0.27-0.22
NCAM2-0.27-0.25
VPS13A-0.26-0.27
NOMO1-0.26-0.25
STARD13-0.26-0.23
RAB21-0.26-0.22
CCDC75-0.26-0.22
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003697single-stranded DNA bindingIDA11809883 
GO:0005515protein bindingIPI2414623 |11427529 |11429708 
|14676842 |17715146 
GO:0005524ATP bindingIEA-
GO:0030983mismatched DNA bindingIEA-
GO:0032137guanine/thymine mispair bindingIEA-
GO:0032137guanine/thymine mispair bindingIMP16713580 
GO:0032407MutSalpha complex bindingIDA16403449 
GO:0043566structure-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000239pachyteneIEA-
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningIEA-
GO:0000712resolution of meiotic joint molecules as recombinantsIEA-
GO:0006303double-strand break repair via nonhomologous end joiningIEA-
GO:0006298mismatch repairIEA-
GO:0006298mismatch repairIMP11555625 
GO:0006298mismatch repairTAS8128251 
GO:0007283spermatogenesisIEA-
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosisIEA-
GO:0007060male meiosis chromosome segregationIEA-
GO:0048477oogenesisIEA-
GO:0016446somatic hypermutation of immunoglobulin genesIEA-
GO:0051257spindle midzone assembly involved in meiosisIEA-
GO:0043060meiotic metaphase I plate congressionIEA-
GO:0045950negative regulation of mitotic recombinationIEA-
GO:0045190isotype switchingIEA-
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000793condensed chromosomeIEA-
GO:0000795synaptonemal complexIEA-
GO:0005634nucleusIC11809883 
GO:0005634nucleusIEA-
GO:0032389MutLalpha complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunitTwo-hybridBioGRID16189514 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedCo-purificationBioGRID10783165 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndrome-HPRD,BioGRID11691925 
MLH1 interacts with BLM.BIND11691925 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10783165 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1E2F1 interacts with the MLH1 promoter.BIND11799067 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with the MLH1 promoter region.BIND11799067 
EXO1HEX1 | hExoIexonuclease 1The exonuclease hEXO1b interacts with the mismatch repair protein hMLH1.BIND11429708 
The exonuclease HEX1 interacts with the mismatch repair protein hMLH1.BIND11429708 
-HPRD,BioGRID11427529 
FRMD6C14orf31 | EX1 | MGC17921 | Willin | c14_5320FERM domain containing 6Two-hybridBioGRID16189514 
MBD4MED1methyl-CpG binding domain protein 4-HPRD,BioGRID10097147 
MLH1 and interacts with MED1.BIND10097147 
MLH3HNPCC7 | MGC138372mutL homolog 3 (E. coli)-HPRD,BioGRID11292842 
hMLH1 interacts with hMLH3.BIND11292842 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Co-purificationBioGRID10783165 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)Co-purificationBioGRID10783165 
MSH4-mutS homolog 4 (E. coli)MLH1 interacts with MSH4.BIND10928988 
-HPRD,BioGRID10928988 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)Co-purificationBioGRID10783165 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12584560 
MLH1 interacts with Myc.BIND12584560 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinCo-purificationBioGRID10783165 
PMS1DKFZp781M0253 | FLJ98259 | HNPCC3 | PMSL1 | hPMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)hPMS1 interacts with hMLH1.BIND11292842 
-HPRD,BioGRID11292842 
PMS2HNPCC4 | PMS2CL | PMSL2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)hMLH1 interacts with hPMS2.BIND11292842 
-HPRD,BioGRID10037723 |11292842 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)Co-purificationBioGRID10783165 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaCo-purificationBioGRID10783165 
TRIM29ATDC | FLJ36085tripartite motif-containing 29Two-hybridBioGRID16189514 
UBOX5KIAA0860 | RNF37 | UBCE7IP5 | UIP5U-box domain containing 5Two-hybridBioGRID16189514 
ZC3H11ADKFZp686D03108 | DKFZp686F14109 | DKFZp781G2455 | KIAA0663 | ZC3HDC11Azinc finger CCCH-type containing 11ATwo-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MISMATCH_REPAIR 2314All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_MEIOTIC_RECOMBINATION 8662All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP 8443All SZGR genes in this pathway
KOINUMA_COLON_CANCER_MSI_DN 85All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
ZUCCHI_METASTASIS_UP 4324All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER 4930All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 2317All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C7 6844All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_UP 8847All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
MATZUK_MEIOTIC_AND_DNA_REPAIR 3926All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway


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