Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: MSN

Summary

GeneID

4478

Symbol

MSN

Synonyms

Description

moesin

Locus tag

Gene type

protein-coding

Map location

Xq11.2-q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.004

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ENHO

0.92

0.89

SCRG1

0.91

0.93

MT1E

0.90

0.97

MT1G

0.89

S100A13

0.88

0.92

C2orf82

0.88

AC044839.2

0.87

0.91

PSMB8

0.87

0.90

TMEM219

0.86

0.79

CBR3

0.86

Top 10 negatively co-expressed genes

MCM3AP

-0.72

-0.84

PDXDC1

-0.72

-0.84

USP7

-0.71

-0.80

CKAP5

-0.71

-0.85

HEATR5B

-0.71

-0.85

GIGYF2

-0.71

-0.81

RBM26

-0.71

-0.85

ABCF1

-0.71

-0.76

RNASEN

-0.71

-0.88

ANKRD17

-0.71

-0.81

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005102

receptor binding

IPI

Neurotransmitter (GO term level: 4)

15819698

GO:0005200

structural constituent of cytoskeleton

TAS

1924289

GO:0008092

cytoskeletal protein binding

IEA

GO:0050839

cell adhesion molecule binding

IPI

12082081

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0022614

membrane to membrane docking

IEP

12082081

GO:0006928

cell motion

TAS

16130169

GO:0007159

leukocyte adhesion

IEP

12082081

GO:0050900

leukocyte migration

IEP

12082081

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0030175

filopodium

IDA

axon (GO term level: 5)

12082081

GO:0001931

uropod

IEA

Synap (GO term level: 5)

GO:0005856

cytoskeleton

TAS

16130169

GO:0005737

cytoplasm

IEA

GO:0005902

microvillus

IDA

12082081

GO:0005886

plasma membrane

TAS

1924289 |8188263

GO:0016323

basolateral plasma membrane

IEA

GO:0016324

apical plasma membrane

IEA

GO:0019898

extrinsic to membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Co-purification	BioGRID	15659383
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Co-purification	BioGRID	15659383
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Co-purification	BioGRID	15659383
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Co-purification	BioGRID	15659383
CD46	MCP \| MGC26544 \| MIC10 \| TLX \| TRA2.10	CD46 molecule, complement regulatory protein	-	HPRD	7884872\|12082081
CD46	MCP \| MGC26544 \| MIC10 \| TLX \| TRA2.10	CD46 molecule, complement regulatory protein	-	HPRD,BioGRID	7884872
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	Moesin interacts with CD93.	BIND	15819698
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD,BioGRID	7579708 \|8248180
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	Co-purification	BioGRID	15659383
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Co-purification	BioGRID	15659383
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	Co-purification	BioGRID	15659383
HLA-B	AS \| HLA-B-7301 \| HLA-B73 \| HLAB \| HLAC \| SPDA1	major histocompatibility complex, class I, B	Affinity Capture-MS	BioGRID	17353931
ICAM1	BB2 \| CD54 \| P3.58	intercellular adhesion molecule 1	-	HPRD	12082081
ICAM2	CD102	intercellular adhesion molecule 2	-	HPRD,BioGRID	9472040
ICAM3	CD50 \| CDW50 \| ICAM-R	intercellular adhesion molecule 3	-	HPRD,BioGRID	11784723
L1CAM	CAML1 \| CD171 \| HSAS \| HSAS1 \| MASA \| MIC5 \| N-CAML1 \| S10 \| SPG1	L1 cell adhesion molecule	-	HPRD	12070130
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Co-purification	BioGRID	15659383
MSN	-	moesin	-	HPRD,BioGRID	10847681
NCF1	FLJ79451 \| NCF1A \| NOXO2 \| SH3PXD1A \| p47phox	neutrophil cytosolic factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	11716484
NCF4	MGC3810 \| NCF \| P40PHOX \| SH3PXD4	neutrophil cytosolic factor 4, 40kDa	-	HPRD,BioGRID	11716484
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	-	HPRD,BioGRID	11441066
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Co-purification	BioGRID	15659383
SELL	CD62L \| LAM-1 \| LAM1 \| LECAM1 \| LNHR \| LSEL \| LYAM1 \| Leu-8 \| Lyam-1 \| PLNHR \| TQ1 \| hLHRc	selectin L	Reconstituted Complex	BioGRID	11706008
SELPLG	CD162 \| CLA \| PSGL-1 \| PSGL1	selectin P ligand	-	HPRD,BioGRID	12115638
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	moesin interacts with hNHE-RF.	BIND	9430655
SLC9A3R1	EBP50 \| NHERF \| NHERF1 \| NPHLOP2		-	HPRD,BioGRID	9430655
SPN	CD43 \| GPL115 \| LSN	sialophorin	-	HPRD,BioGRID	9616160
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Syk interacts with moesin. This interaction was modeled on a demonstrated interaction between Syk and moesin from unspecified species.	BIND	12387735
TNFRSF10B	CD262 \| DR5 \| KILLER \| KILLER/DR5 \| TRAIL-R2 \| TRAILR2 \| TRICK2 \| TRICK2A \| TRICK2B \| TRICKB \| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	Co-purification	BioGRID	15659383
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	Co-purification	BioGRID	15659383
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	-	HPRD,BioGRID	12226091
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Hamartin interacts with moesin. This interaction was modeled on a demonstrated interaction between murine hamartin and human moesin.	BIND	10806479
VCAM1	CD106 \| DKFZp779G2333 \| INCAM-100 \| MGC99561	vascular cell adhesion molecule 1	-	HPRD,BioGRID	12082081
VCAM1	CD106 \| DKFZp779G2333 \| INCAM-100 \| MGC99561	vascular cell adhesion molecule 1	-	HPRD	7884872\|12082081

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
PID_RHOA_PATHWAY	45	33	All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY	41	35	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1	27	15	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP	783	507	All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP	351	230	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP	255	177	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN	455	304	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN	460	312	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP	536	340	All SZGR genes in this pathway
LANG_MYB_FAMILY_TARGETS	29	16	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B	392	251	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_HIGH_RECURRENCE	49	31	All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL	330	215	All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP	83	51	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP	358	245	All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP	292	168	All SZGR genes in this pathway
WU_CELL_MIGRATION	184	114	All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX	230	156	All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215	893	528	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN	309	206	All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC	182	116	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
LEI_MYB_TARGETS	318	215	All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_UP	86	55	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8	86	57	All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2	163	113	All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST	132	93	All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED	728	415	All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP	66	44	All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN	564	326	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP	648	398	All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP	81	53	All SZGR genes in this pathway
NUTT_GBM_VS_AO_GLIOMA_UP	46	34	All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_UP	212	128	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN	240	153	All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES	389	245	All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1	237	159	All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN	253	192	All SZGR genes in this pathway
DANG_MYC_TARGETS_DN	31	25	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP	127	78	All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN	374	217	All SZGR genes in this pathway
DEMAGALHAES_AGING_UP	55	39	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN	315	215	All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP	163	111	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-122	48	54	m8	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-133	140	147	1A,m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	140	147	1A,m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-192/215	1601	1607	m8	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	1601	1607	m8	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-200bc/429	1574	1581	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-217	1703	1709	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-27	1794	1800	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1794	1800	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-491	43	50	1A,m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-96	2012	2018	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	2012	2018	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.