Gene Page: MYH9

Summary
GeneID  4627
Symbol  MYH9
Synonyms  DFNA17|EPSTS|FTNS|MGC104539|MHA|NMHC-II-A|NMMHCA
Description  myosin, heavy chain 9, non-muscle
See related  HGNC:7579|MIM:160775|Ensembl:ENSG00000100345|HPRD:01177|
Locus tag  RP1-68O2.1
Gene type  protein-coding
Map location  22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0354 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000146microfilament motor activityIDA12237319 
GO:0000166nucleotide bindingIEA-
GO:0003779actin bindingIEA-
GO:0003774motor activityIEA-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIDA15065866 |15845534 
GO:0005524ATP bindingIEA-
GO:0016887ATPase activityIDA12237319 
GO:0043495protein anchorIMP16403913 
GO:0051015actin filament bindingIDA12237319 |14508515 
GO:0051015actin filament bindingNAS16403913 
GO:0042803protein homodimerization activityIDA12237319 
GO:0030898actin-dependent ATPase activityIDA15065866 |15845534 
GO:0043531ADP bindingIDA15065866 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000212meiotic spindle organizationIEA-
GO:0000904cell morphogenesis involved in differentiationIEA-
GO:0000910cytokinesisIMP15774463 
GO:0001525angiogenesisIDA16403913 
GO:0001701in utero embryonic developmentIEA-
GO:0001768establishment of T cell polarityIEA-
GO:0030224monocyte differentiationIEP1912569 
GO:0007132meiotic metaphase IIEA-
GO:0006509membrane protein ectodomain proteolysisIDA16186248 
GO:0007229integrin-mediated signaling pathwayNAS10822899 
GO:0008360regulation of cell shapeIMP11029059 
GO:0007605sensory perception of soundIEA-
GO:0030048actin filament-based movementIDA12237319 
GO:0007520myoblast fusionIEA-
GO:0006928cell motionIEA-
GO:0016337cell-cell adhesionIEA-
GO:0032796uropod organizationIEA-
GO:0015031protein transportIMP16403913 
GO:0031532actin cytoskeleton reorganizationIMP15869600 
GO:0051295establishment of meiotic spindle localizationIEA-
GO:0030220platelet formationIMP12237319 
GO:0043534blood vessel endothelial cell migrationIMP16403913 
GO:0050900leukocyte migrationNAS12421915 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001772immunological synapseIDASynap (GO term level: 7)15064761 
GO:0031594neuromuscular junctionIEAneuron, axon, Synap, Neurotransmitter (GO term level: 3)-
GO:0001931uropodIDASynap (GO term level: 5)15064761 
GO:0001725stress fiberIDA7699007 |14508515 |14706930 
|16403913 
GO:0001726ruffleIDA16403913 
GO:0005819spindleIEA-
GO:0005826contractile ringIDA11029059 
GO:0005829cytosolIDA14508515 
GO:0005634nucleusIDA14508515 
GO:0005737cytoplasmIDA7699007 
GO:0005938cell cortexIEA-
GO:0005913cell-cell adherens junctionIEA-
GO:0005886plasma membraneIDA16186248 |16403913 
GO:0008305integrin complexIDA10822899 
GO:0016459myosin complexIEA-
GO:0032154cleavage furrowIDA7699007 |14508515 
GO:0030863cortical cytoskeletonIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Two-hybridBioGRID16169070 
CD163M130 | MM130CD163 molecule-HPRD15479433 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Affinity Capture-MSBioGRID17353931 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4Affinity Capture-MSBioGRID14594945 
MYL9LC20 | MGC3505 | MLC2 | MRLC1 | MYRL2myosin, light chain 9, regulatoryTwo-hybridBioGRID16169070 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilonAffinity Capture-MS
Affinity Capture-Western		BioGRID11897493 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD9405067 |15289939 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_DN 7351All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22 139All SZGR genes in this pathway
XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_DN 2012All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
CHESLER_BRAIN_QTL_TRANS 65All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_UP 1713All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN 9671All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN 2818All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS 7849All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_UP 6643All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_CURCUMIN_SULINDAC_TSA_1 107All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
IKEDA_MIR133_TARGETS_UP 4327All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1071831891Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-124.112971303m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506129613031A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1337877941A,m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-142-3p132413301Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1498338391Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-19910751081m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-25/32/92/363/367672678m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p133913451Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-410128312891Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-542-3p13171323m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
miR-92262331A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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