Gene Page: MYO5A

Summary
GeneID  4644
Symbol  MYO5A
Synonyms  GS1|MYH12|MYO5|MYR12
Description  myosin VA (heavy chain 12, myoxin)
See related  HGNC:7602|MIM:160777|Ensembl:ENSG00000197535|HPRD:01179|
Locus tag  -
Gene type  protein-coding
Map location  15q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SSRP10.960.95
ING10.960.95
U2AF20.950.96
HNRNPA00.950.95
HNRNPUL10.940.95
DDX230.940.95
RPIA0.940.94
ZCCHC30.940.93
SMARCB10.940.90
ZNF2120.940.94
Top 10 negatively co-expressed genes
AF347015.31-0.74-0.89
C5orf53-0.73-0.76
AF347015.27-0.73-0.89
MT-CO2-0.72-0.88
AF347015.33-0.71-0.87
HLA-F-0.71-0.76
FXYD1-0.71-0.84
S100B-0.70-0.80
IFI27-0.69-0.82
MT-CYB-0.69-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000146microfilament motor activityNAS10448864 
GO:0000166nucleotide bindingIEA-
GO:0003774motor activityIEA-
GO:0003674molecular_functionND-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIEA-
GO:0051015actin filament bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
GO:0030048actin filament-based movementNAS10448864 
GO:0006810transportNAS11980908 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionNASneuron, axon, neurite, dendrite (GO term level: 5)10391919 
GO:0030426growth coneNASaxon, dendrite (GO term level: 5)10391919 
GO:0001726ruffleIDA9852149 
GO:0005813centrosomeIDA18029348 
GO:0005737cytoplasmIDA9852149 
GO:0005925focal adhesionIDA18029348 
GO:0016459myosin complexIEA-
GO:0016459myosin complexNAS9826529 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMFFLJ00065Bcl2 modifying factorReconstituted ComplexBioGRID11546872 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1Reconstituted ComplexBioGRID10844022 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD,BioGRID10844022 
DLC8 interacts with Myosin V. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human Myosin V.BIND11148209 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10844022 |11546872 
MLPHMGC2771 | MGC59733 | SLAC2-Amelanophilin-HPRD,BioGRID11856727 |11980908 
|12006666 |12062444 
|14730011 |15059972 
RAB27AGS2 | HsT18676 | MGC117246 | RAB27 | RAMRAB27A, member RAS oncogene family-HPRD,BioGRID12006666 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2Affinity Capture-WesternBioGRID10844022 
TRIM2KIAA0517 | RNF86tripartite motif-containing 2-HPRD11432975 
TRIM3BERP | FLJ16135 | HAC1 | RNF22 | RNF97tripartite motif-containing 3-HPRD10391919 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 2115All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
WIKMAN_ASBESTOS_LUNG_CANCER_DN 2813All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
LIAN_LIPA_TARGETS_6M 7447All SZGR genes in this pathway
LIAN_LIPA_TARGETS_3M 5936All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_UP 4831All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1486648721Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506489849041Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1451291361A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1904484551A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-25/32/92/363/367177117781A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p7027091A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-539496549711Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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