Gene Page: NCL

Summary
GeneID  4691
Symbol  NCL
Synonyms  C23|FLJ45706
Description  nucleolin
See related  HGNC:7667|MIM:164035|Ensembl:ENSG00000115053|HPRD:01245|
Locus tag  -
Gene type  protein-coding
Map location  2q12-qter
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0143 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC116610.11.001.00
ZNHIT10.870.75
COX8A0.860.75
TRAPPC50.860.76
NDUFB70.850.71
NDUFA110.850.70
MRP630.850.74
C7orf590.850.72
C19orf700.850.75
NDUFA20.840.73
Top 10 negatively co-expressed genes
BAT2D1-0.44-0.41
RBM25-0.41-0.44
MYH9-0.40-0.37
ZC3H13-0.39-0.37
UPF2-0.38-0.34
ZNHIT6-0.37-0.34
MACF1-0.37-0.34
SFRS12-0.37-0.41
MDN1-0.36-0.33
SLC6A6-0.36-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003677DNA bindingIEA-
GO:0003723RNA bindingTAS2737305 
GO:0005515protein bindingIEA-
GO:0008022protein C-terminus bindingIPI16403913 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001525angiogenesisIDA16403913 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA12944467 
GO:0005730nucleolusIEA-
GO:0005938cell cortexIDA16403913 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAP1CENTA1 | GCS1L | p42IP4ArfGAP with dual PH domains 1-HPRD,BioGRID12565890 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)Reconstituted ComplexBioGRID11115514 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD2192260|8663258 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptideAffinity Capture-Western
Biochemical Activity
Far Western		BioGRID8663258 
CYFIP1FLJ45151 | P140SRA-1 | SHYC | SRA1cytoplasmic FMR1 interacting protein 1Affinity Capture-WesternBioGRID11438699 
FMR1FMRP | FRAXA | MGC87458 | POF | POF1fragile X mental retardation 1Affinity Capture-WesternBioGRID10567518 
GZMACTLA3 | HFSPgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)-HPRD1860869 
MDKFLJ27379 | MK | NEGF2midkine (neurite growth-promoting factor 2)-HPRD,BioGRID12147681 
MYBCmyb | c-myb | c-myb_CDS | efgv-myb myeloblastosis viral oncogene homolog (avian)Affinity Capture-WesternBioGRID10660576 
MYBL1A-MYB | AMYB | MGC120059 | MGC120061v-myb myeloblastosis viral oncogene homolog (avian)-like 1Affinity Capture-Western
Far Western		BioGRID10660576 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Ncl (nucleolin) interacts with Myc (c-Myc).BIND15674325 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)-HPRD,BioGRID8620867 |10503877 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID8530516 |11162542 
PPARGC1ALEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1peroxisome proliferator-activated receptor gamma, coactivator 1 alpha-HPRD10983978 
PPP1CBMGC3672 | PP-1B | PPP1CDprotein phosphatase 1, catalytic subunit, beta isoformAffinity Capture-WesternBioGRID12185196 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID9388266 
S100A11MLN70 | S100CS100 calcium binding protein A11-HPRD,BioGRID14623863 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
SP1-Sp1 transcription factorAffinity Capture-WesternBioGRID14623863 
SSBLARP3 | LaSjogren syndrome antigen B (autoantigen La)Affinity Capture-MS
Affinity Capture-Western		BioGRID12096904 
SWAP70FLJ39540 | HSPC321 | KIAA0640 | SWAP-70SWAP-70 protein-HPRD,BioGRID9642267 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptaseAffinity Capture-Western
Reconstituted Complex		BioGRID15371412 
nucleolin interacts with hTERT.BIND15371412 
TOP1TOPItopoisomerase (DNA) ITop1 interacts with NucleolinBIND10967121 
-HPRD,BioGRID8567649 |9512561 
|10967121 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID12138209 
TROVE2RO60 | SSA2TROVE domain family, member 2-HPRD12096904 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
BIOCARTA_SARS_PATHWAY 105All SZGR genes in this pathway
PID_AURORA_B_PATHWAY 3924All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY 7962All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_UP 2317All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN 4734All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
DEN_INTERACT_WITH_LCA5 2621All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
COLLER_MYC_TARGETS_UP 2519All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP 6544All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_4HR 5436All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR 5538All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN 5443All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_UP 7445All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20690971A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1945763m8hsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-431961021Ahsa-miR-431UGUCUUGCAGGCCGUCAUGCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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