Gene Page: SEPT2

Summary
GeneID  4735
Symbol  SEPT2
Synonyms  DIFF6|KIAA0158|NEDD5|Pnutl3|hNedd5
Description  septin 2
See related  HGNC:7729|MIM:601506|Ensembl:ENSG00000168385|HPRD:03297|
Locus tag  -
Gene type  protein-coding
Map location  2q37
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0778 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TIAM20.930.86
EML10.920.82
FOXG1B0.920.91
TMEM1080.910.87
TP53I110.900.88
DAB10.900.89
SEZ60.890.84
NCK20.890.84
DACT10.890.87
ZNF2380.890.93
Top 10 negatively co-expressed genes
SERPINB6-0.64-0.70
AP003117.1-0.61-0.62
AIFM3-0.61-0.74
HEPN1-0.60-0.70
C5orf53-0.60-0.65
AC007405.8-0.60-0.67
HLA-F-0.60-0.68
ALDOC-0.59-0.64
FBXO2-0.59-0.57
LDHD-0.59-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI10321247 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA10942595 
GO:0005737cytoplasmIDA10942595 
GO:0031105septin complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DAZAP2KIAA0058 | MGC14319 | MGC766 | PRTBDAZ associated protein 2Two-hybridBioGRID16189514 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD14531065 
SEPT5CDCREL | CDCREL-1 | CDCREL1 | H5 | PNUTL1septin 5-HPRD10321247 
SEPT6KIAA0128 | MGC16619 | MGC20339 | SEP2 | SEPT2septin 6Affinity Capture-Western
Two-hybrid		BioGRID12388755 |16189514 
SEPT7CDC10 | CDC3 | Nbla02942 | SEPT7Aseptin 7Affinity Capture-MS
Affinity Capture-Western		BioGRID12388755 |17353931 
SEPT9AF17q25 | FLJ75490 | KIAA0991 | MSF | MSF1 | NAPB | PNUTL4 | SINT1 | SeptD1septin 9-HPRD,BioGRID12388755 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)Affinity Capture-WesternBioGRID12695511 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD10321247 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
SEIDEN_MET_SIGNALING 1916All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C6 3927All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
NGO_MALIGNANT_GLIOMA_1P_LOH 1713All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/4975425491A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-485-3p1711781A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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