Gene Page: NF1

Summary
GeneID  4763
Symbol  NF1
Synonyms  DKFZp686J1293|FLJ21220|NFNS|VRNF|WSS
Description  neurofibromin 1
See related  HGNC:7765|MIM:162200|Ensembl:ENSG00000196712|HPRD:01203|
Locus tag  -
Gene type  protein-coding
Map location  17q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 12 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CRIP20.880.88
HTRA20.870.86
PIK3R20.860.87
C19orf220.860.87
CHMP1A0.850.84
UNC1190.850.85
KLHL220.850.86
ADCK20.850.84
TBCB0.850.83
TOR3A0.840.86
Top 10 negatively co-expressed genes
MT-CO2-0.71-0.73
AF347015.33-0.70-0.74
AF347015.8-0.70-0.74
AF347015.27-0.70-0.74
MT-CYB-0.70-0.74
AF347015.26-0.68-0.76
AF347015.31-0.68-0.71
AF347015.15-0.67-0.72
AF347015.2-0.66-0.72
AF347015.21-0.63-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005099Ras GTPase activator activityIDA1568247 |1570015 
GO:0005096GTPase activator activityIEA-
GO:0005515protein bindingIPI11356864 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentISSBrain (GO term level: 7)-
GO:0007406negative regulation of neuroblast proliferationISSneurogenesis (GO term level: 10)-
GO:0022011myelination in the peripheral nervous systemISSneuron, axon, dendrite (GO term level: 14)-
GO:0048715negative regulation of oligodendrocyte differentiationISSoligodendrocyte, Glial (GO term level: 12)-
GO:0021897forebrain astrocyte developmentISSneuron, astrocyte, Brain, Glial (GO term level: 11)-
GO:0048485sympathetic nervous system developmentISSneuron, Neurotransmitter (GO term level: 7)-
GO:0045685regulation of glial cell differentiationISSGlial (GO term level: 10)-
GO:0021510spinal cord developmentISSBrain (GO term level: 7)-
GO:0048853forebrain morphogenesisISSBrain (GO term level: 9)-
GO:0043525positive regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0001666response to hypoxiaISS-
GO:0001656metanephros developmentISS-
GO:0001649osteoblast differentiationISS-
GO:0001889liver developmentISS-
GO:0001937negative regulation of endothelial cell proliferationIMP17404841 
GO:0001952regulation of cell-matrix adhesionISS-
GO:0042992negative regulation of transcription factor import into nucleusISS-
GO:0007265Ras protein signal transductionISS-
GO:0007165signal transductionIEA-
GO:0008542visual learningISS-
GO:0008150biological_processND-
GO:0007507heart developmentISS-
GO:0007422peripheral nervous system developmentISS-
GO:0014065phosphoinositide 3-kinase cascadeISS-
GO:0042060wound healingISS-
GO:0030036actin cytoskeleton organizationISS-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
GO:0021987cerebral cortex developmentISS-
GO:0043473pigmentationISS-
GO:0030199collagen fibril organizationISS-
GO:0032320positive regulation of Ras GTPase activityISS-
GO:0030336negative regulation of cell migrationIMP16648142 
GO:0030325adrenal gland developmentISS-
GO:0043409negative regulation of MAPKKK cascadeISS-
GO:0048745smooth muscle developmentISS-
GO:0043407negative regulation of MAP kinase activityISS-
GO:0045762positive regulation of adenylate cyclase activityISS-
GO:0045765regulation of angiogenesisIMP17404841 
GO:0045786negative regulation of cell cycleIEA-
GO:0045124regulation of bone resorptionISS-
GO:0043535regulation of blood vessel endothelial cell migrationIMP17404841 
GO:0048593camera-type eye morphogenesisISS-
GO:0050890cognitionIMP17299016 
GO:0048844artery morphogenesisISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteIDAneuron, axon, dendrite (GO term level: 6)1550670 
GO:0030424axonIDAneuron, axon, Neurotransmitter (GO term level: 6)1550670 
GO:0005575cellular_componentND-
GO:0005622intracellularIEA-
GO:0005634nucleusISS1550670 
GO:0005737cytoplasmISS1550670 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DNAJC7DANJC7 | DJ11 | TPR2 | TTC2DnaJ (Hsp40) homolog, subfamily C, member 7-HPRD8836031 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID8628317 
MYOGMYF4 | MYOGENIN | bHLHc3myogenin (myogenic factor 4)Reconstituted ComplexBioGRID1329097 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_RAS_PATHWAY 3022All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_DN 5234All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_UP 13582All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
RODRIGUES_NTN1_AND_DCC_TARGETS 3525All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12 118All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
COURTOIS_SENESCENCE_TRIGGERS 65All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_DN 3121All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_FREQUENTLY 1210All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_UP 4532All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_MUTATED 88All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-109149201Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-103/107177183m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-128119512021A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1376506561Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-153297429801Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-182173317401A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-27119612031A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p170217091A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-369-3p31193125m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-370335833651A,m8hsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-3782672741A,m8hsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-381326432701Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-448297429801Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-485-5p5405461Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-4866596651Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-49014351441m8hsa-miR-490CAACCUGGAGGACUCCAUGCUG
miR-496164516511Ahsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
miR-543296929751Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-96173417401Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.