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GeneID |
4763
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Symbol |
NF1
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Synonyms |
DKFZp686J1293|FLJ21220|NFNS|VRNF|WSS
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Description |
neurofibromin 1 |
See related |
HGNC:7765|MIM:162200|Ensembl:ENSG00000196712|HPRD:01203| |
Locus tag |
- |
Gene type |
protein-coding |
Map location |
17q11.2 |
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Gene set name |
Method of gene set |
Evidence |
Info |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 12 | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0086 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
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Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
CRIP2 | 0.88 | 0.88 | | |
HTRA2 | 0.87 | 0.86 | | |
PIK3R2 | 0.86 | 0.87 | | |
C19orf22 | 0.86 | 0.87 | | |
CHMP1A | 0.85 | 0.84 | | |
UNC119 | 0.85 | 0.85 | | |
KLHL22 | 0.85 | 0.86 | | |
ADCK2 | 0.85 | 0.84 | | |
TBCB | 0.85 | 0.83 | | |
TOR3A | 0.84 | 0.86 | | |
Top 10 negatively co-expressed genes | MT-CO2 | -0.71 | -0.73 | | |
AF347015.33 | -0.70 | -0.74 | | |
AF347015.8 | -0.70 | -0.74 | | |
AF347015.27 | -0.70 | -0.74 | | |
MT-CYB | -0.70 | -0.74 | | |
AF347015.26 | -0.68 | -0.76 | | |
AF347015.31 | -0.68 | -0.71 | | |
AF347015.15 | -0.67 | -0.72 | | |
AF347015.2 | -0.66 | -0.72 | | |
AF347015.21 | -0.63 | -0.70 | | |
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Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0003674 | molecular_function | ND | | - |
GO:0005099 | Ras GTPase activator activity | IDA | | 1568247 |1570015 |
GO:0005096 | GTPase activator activity | IEA | | - |
GO:0005515 | protein binding | IPI | | 11356864 |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007420 | brain development | ISS | Brain (GO term level: 7) | - |
GO:0007406 | negative regulation of neuroblast proliferation | ISS | neurogenesis (GO term level: 10) | - |
GO:0022011 | myelination in the peripheral nervous system | ISS | neuron, axon, dendrite (GO term level: 14) | - |
GO:0048715 | negative regulation of oligodendrocyte differentiation | ISS | oligodendrocyte, Glial (GO term level: 12) | - |
GO:0021897 | forebrain astrocyte development | ISS | neuron, astrocyte, Brain, Glial (GO term level: 11) | - |
GO:0048485 | sympathetic nervous system development | ISS | neuron, Neurotransmitter (GO term level: 7) | - |
GO:0045685 | regulation of glial cell differentiation | ISS | Glial (GO term level: 10) | - |
GO:0021510 | spinal cord development | ISS | Brain (GO term level: 7) | - |
GO:0048853 | forebrain morphogenesis | ISS | Brain (GO term level: 9) | - |
GO:0043525 | positive regulation of neuron apoptosis | ISS | neuron (GO term level: 9) | - |
GO:0001666 | response to hypoxia | ISS | | - |
GO:0001656 | metanephros development | ISS | | - |
GO:0001649 | osteoblast differentiation | ISS | | - |
GO:0001889 | liver development | ISS | | - |
GO:0001937 | negative regulation of endothelial cell proliferation | IMP | | 17404841 |
GO:0001952 | regulation of cell-matrix adhesion | ISS | | - |
GO:0042992 | negative regulation of transcription factor import into nucleus | ISS | | - |
GO:0007265 | Ras protein signal transduction | ISS | | - |
GO:0007165 | signal transduction | IEA | | - |
GO:0008542 | visual learning | ISS | | - |
GO:0008150 | biological_process | ND | | - |
GO:0007507 | heart development | ISS | | - |
GO:0007422 | peripheral nervous system development | ISS | | - |
GO:0014065 | phosphoinositide 3-kinase cascade | ISS | | - |
GO:0042060 | wound healing | ISS | | - |
GO:0030036 | actin cytoskeleton organization | ISS | | - |
GO:0051056 | regulation of small GTPase mediated signal transduction | IEA | | - |
GO:0021987 | cerebral cortex development | ISS | | - |
GO:0043473 | pigmentation | ISS | | - |
GO:0030199 | collagen fibril organization | ISS | | - |
GO:0032320 | positive regulation of Ras GTPase activity | ISS | | - |
GO:0030336 | negative regulation of cell migration | IMP | | 16648142 |
GO:0030325 | adrenal gland development | ISS | | - |
GO:0043409 | negative regulation of MAPKKK cascade | ISS | | - |
GO:0048745 | smooth muscle development | ISS | | - |
GO:0043407 | negative regulation of MAP kinase activity | ISS | | - |
GO:0045762 | positive regulation of adenylate cyclase activity | ISS | | - |
GO:0045765 | regulation of angiogenesis | IMP | | 17404841 |
GO:0045786 | negative regulation of cell cycle | IEA | | - |
GO:0045124 | regulation of bone resorption | ISS | | - |
GO:0043535 | regulation of blood vessel endothelial cell migration | IMP | | 17404841 |
GO:0048593 | camera-type eye morphogenesis | ISS | | - |
GO:0050890 | cognition | IMP | | 17299016 |
GO:0048844 | artery morphogenesis | ISS | | - |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0030425 | dendrite | IDA | neuron, axon, dendrite (GO term level: 6) | 1550670 |
GO:0030424 | axon | IDA | neuron, axon, Neurotransmitter (GO term level: 6) | 1550670 |
GO:0005575 | cellular_component | ND | | - |
GO:0005622 | intracellular | IEA | | - |
GO:0005634 | nucleus | ISS | | 1550670 |
GO:0005737 | cytoplasm | ISS | | 1550670 |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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