Gene Page: NOS3

Summary
GeneID  4846
Symbol  NOS3
Synonyms  ECNOS|eNOS
Description  nitric oxide synthase 3 (endothelial cell)
See related  HGNC:7876|MIM:163729|Ensembl:ENSG00000164867|HPRD:01224|
Locus tag  -
Gene type  protein-coding
Map location  7q36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003785actin monomer bindingIPI17502619 
GO:0005506iron ion bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0004517nitric-oxide synthase activityIEA-
GO:0020037heme bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0010181FMN bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0034617tetrahydrobiopterin bindingIDA7488039 
GO:0034618arginine bindingIDA7488039 
GO:0046870cadmium ion bindingNAS7488039 
GO:0050660FAD bindingIEA-
GO:0050661NADP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001542ovulation from ovarian follicleIEA-
GO:0002028regulation of sodium ion transportIEA-
GO:0003100regulation of systemic arterial blood pressure by endothelinIMP8999856 
GO:0001974blood vessel remodelingISS-
GO:0006527arginine catabolic processIDA1378832 |7488039 
GO:0008217regulation of blood pressureNAS7504210 
GO:0010544negative regulation of platelet activationNAS7504210 
GO:0008285negative regulation of cell proliferationISS-
GO:0009408response to heatNAS18048451 
GO:0007612learningIEA-
GO:0006809nitric oxide biosynthetic processIEA-
GO:0007005mitochondrion organizationISS-
GO:0006916anti-apoptosisISS-
GO:0014740negative regulation of muscle hyperplasiaISS-
GO:0014806smooth muscle hyperplasiaISS-
GO:0051346negative regulation of hydrolase activityIEA-
GO:0031284positive regulation of guanylate cyclase activityIMP17502619 
GO:0031284positive regulation of guanylate cyclase activityISS-
GO:0034405response to fluid shear stressIEP10376603 
GO:0030324lung developmentIEA-
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA-
GO:0043267negative regulation of potassium ion transportIEA-
GO:0045766positive regulation of angiogenesisISS-
GO:0045909positive regulation of vasodilationNAS18048451 
GO:0050880regulation of blood vessel sizeISS-
GO:0050880regulation of blood vessel sizeNAS7504210 
GO:0043542endothelial cell migrationIMP8999856 
GO:0055114oxidation reductionIEA-
GO:0051926negative regulation of calcium ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneEXP9188442 |9580552 |10781589 
|11149895 |16722822 
|16807357 
GO:0005794Golgi apparatusIEA-
GO:0005829cytosolEXP7512951 |10559837 
GO:0005856cytoskeletonIEA-
GO:0005634nucleusISS-
GO:0005737cytoplasmIEA-
GO:0005901caveolaIDA17502619 |17848177 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BDKRB2B2R | BK-2 | BK2 | BKR2 | BRB2 | DKFZp686O088bradykinin receptor B2-HPRD10681501 
BDNFMGC34632brain-derived neurotrophic factor-HPRD10493752 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID8910295 
EDNRBABCDS | ETB | ETBR | ETRB | HSCR | HSCR2endothelin receptor type B-HPRD10510297 
GUCY1B3GC-S-beta-1 | GC-SB3 | GUC1B3 | GUCB3 | GUCSB3 | GUCY1B1guanylate cyclase 1, soluble, beta 3Affinity Capture-Western
Reconstituted Complex		BioGRID12676772 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID11744239 |12124224 
NOSIPCGI-25nitric oxide synthase interacting protein-HPRD11149895 
NOSTRINDaIP2 | MGC20702nitric oxide synthase trafficker-HPRD,BioGRID12446846 
SP1-Sp1 transcription factor-HPRD7541039 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
BIOCARTA_NO1_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_GCR_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_HIF_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY 2918All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_FRA_PATHWAY 3728All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 139All SZGR genes in this pathway
REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS 3315All SZGR genes in this pathway
REACTOME_ENOS_ACTIVATION_AND_REGULATION 2014All SZGR genes in this pathway
REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 2519All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SANA_TNF_SIGNALING_DN 9057All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP 8349All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
MATZUK_OVULATION 1410All SZGR genes in this pathway
MATZUK_MEIOTIC_AND_DNA_REPAIR 3926All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_DN 4224All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway


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