Gene Page: NPY

Summary
GeneID  4852
Symbol  NPY
Synonyms  PYY4
Description  neuropeptide Y
See related  HGNC:7955|MIM:162640|Ensembl:ENSG00000122585|HPRD:01214|
Locus tag  -
Gene type  protein-coding
Map location  7p15.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C5orf230.970.92
SOX50.900.89
FEZF20.900.86
NFIB0.870.86
XPR10.860.86
NAB10.850.73
PCSK50.850.84
PELI20.850.74
RBPSUH0.840.70
AL512631.10.830.74
Top 10 negatively co-expressed genes
SERPINB6-0.45-0.72
SUOX-0.44-0.02
TNFSF12-0.44-0.59
SLC9A3R2-0.43-0.47
LGI4-0.43-0.35
HDDC2-0.42-0.51
C19orf66-0.42-0.35
NOL3-0.41-0.48
TMEM54-0.40-0.47
RAMP3-0.40-0.21
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005184neuropeptide hormone activityTASaxon, Synap, Brain, Neurotransmitter (GO term level: 6)2427515 
GO:0001664G-protein-coupled receptor bindingIEA-
GO:0004930G-protein coupled receptor activityTAS1321422 
GO:0005246calcium channel regulator activityTAS8132547 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)10557353 
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS8132547 
GO:0008217regulation of blood pressureIEA-
GO:0008283cell proliferationTAS10488139 
GO:0008343adult feeding behaviorISS-
GO:0007586digestionNAS8421707 
GO:0006816calcium ion transportTAS8132547 
GO:0006928cell motionTAS10488139 
GO:0032100positive regulation of appetiteISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS-
GO:0005623cellTAS2444979 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GHRLMTLRP | obestatinghrelin/obestatin prepropeptide-HPRD11196643 |12663466 
MC4RMGC126851 | MGC138197melanocortin 4 receptor-HPRD,BioGRID12015205 
MEP1APPHAmeprin A, alpha (PABA peptide hydrolase)Biochemical ActivityBioGRID11278902 
NPFFFMRFALneuropeptide FF-amide peptide precursor-HPRD11325787 
NPFFR2GPR74 | NPFF2 | NPGPRneuropeptide FF receptor 2-HPRD12609745 
NPY1RNPYRneuropeptide Y receptor Y1-HPRD,BioGRID7559383 |9001438|12007534 
NPY2R-neuropeptide Y receptor Y2-HPRD7559383 |9001438 
|12007534|12007534 
NPY5RNPYR5neuropeptide Y receptor Y5-HPRD12007534 
PMCHMCHpro-melanin-concentrating hormone-HPRD,BioGRID12106685 
PPYR1MGC116897 | NPY4-R | NPY4R | PP1 | Y4pancreatic polypeptide receptor 1-HPRD12007534 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_UP 15290All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_UP 1512All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
DE_YY1_TARGETS_UP 2014All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-338389m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-3811341401Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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