Gene Page: NOTCH4

Summary
GeneID  4855
Symbol  NOTCH4
Synonyms  FLJ16302|INT3|MGC74442|NOTCH3
Description  Notch homolog 4 (Drosophila)
See related  HGNC:7884|MIM:164951|Ensembl:ENSG00000204301|HPRD:01290|
Locus tag  DAQB-143M3.4
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NPY5R0.760.86
PROM10.750.63
NPNT0.750.62
GRAP20.740.59
MARCH10.740.82
ARHGAP150.730.60
LMO40.730.84
AC079061.10.720.84
GRM70.720.79
RBM240.720.83
Top 10 negatively co-expressed genes
REEP6-0.50-0.47
UBTD1-0.48-0.59
HSD17B14-0.47-0.63
RHBDL3-0.46-0.59
AIFM3-0.46-0.57
TSC22D4-0.45-0.58
S100B-0.45-0.59
BDH2-0.44-0.59
ACSF2-0.44-0.64
RENBP-0.44-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS11823422 
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS11823422 
GO:0005515protein bindingIPI7671825 
GO:0046982protein heterodimerization activityTAS8681805 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001569patterning of blood vesselsISS-
GO:0001709cell fate determinationTAS11823422 
GO:0001763morphogenesis of a branching structureISS-
GO:0006350transcriptionIEA-
GO:0007219Notch signaling pathwayIEA-
GO:0009790embryonic developmentISS-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0030879mammary gland developmentIDA9576833 
GO:0050793regulation of developmental processIEA-
GO:0030097hemopoiesisTAS11532344 
GO:0045602negative regulation of endothelial cell differentiationISS-
GO:0045893positive regulation of transcription, DNA-dependentTAS11823422 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS8681805 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA11823422 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS11823422 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7-HPRD11585921 
MAML1KIAA0200 | Mam-1 | Mam1mastermind-like 1 (Drosophila)Reconstituted ComplexBioGRID11101851 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 2917All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH4 1210All SZGR genes in this pathway
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 4424All SZGR genes in this pathway
REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 1610All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 138All SZGR genes in this pathway
REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 128All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
LIU_CDX2_TARGETS_UP 3622All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
THEODOROU_MAMMARY_TUMORIGENESIS 3124All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_FREQUENTLY 1210All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
GOLDRATH_IMMUNE_MEMORY 6542All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_DN 2113All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR 2013All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MIKKELSEN_MCV6_LCP_WITH_H3K4ME3 16280All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_ES_LCP_WITH_H3K4ME3 14280All SZGR genes in this pathway
FUKUSHIMA_TNFSF11_TARGETS 1614All SZGR genes in this pathway
KOHOUTEK_CCNT2_TARGETS 5835All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway


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