Gene Page: NTF3

Summary
GeneID  4908
Symbol  NTF3
Synonyms  HDNF|MGC129711|NGF-2|NGF2|NT3
Description  neurotrophin 3
See related  HGNC:8023|MIM:162660|Ensembl:ENSG00000185652|HPRD:01219|
Locus tag  -
Gene type  protein-coding
Map location  12p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RSAD20.850.78
OAS30.830.79
GBP10.800.77
MX20.800.71
PARP120.750.73
HLA-B0.740.66
SLC15A30.740.66
ACSL50.730.75
HLA-A0.730.57
GBP30.720.75
Top 10 negatively co-expressed genes
C17orf48-0.45-0.55
RBMX2-0.45-0.56
ZBED5-0.44-0.52
RBM3-0.44-0.51
MED19-0.44-0.54
ZNF821-0.44-0.49
WDR70-0.44-0.47
BLVRA-0.43-0.50
SAAL1-0.43-0.51
U2AF1-0.43-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005165neurotrophin receptor bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0007403glial cell fate determinationIEAGlial (GO term level: 10)-
GO:0048699generation of neuronsIEAneuron, neurogenesis (GO term level: 7)-
GO:0048666neuron developmentIEAneuron (GO term level: 9)-
GO:0007274neuromuscular synaptic transmissionIEAneuron, Synap (GO term level: 7)-
GO:0048484enteric nervous system developmentIEAneuron (GO term level: 7)-
GO:0042490mechanoreceptor differentiationIEAneuron (GO term level: 9)-
GO:0043523regulation of neuron apoptosisIEAneuron (GO term level: 8)-
GO:0007267cell-cell signalingTAS2236018 
GO:0007165signal transductionTAS2236018 
GO:0008544epidermis developmentIEA-
GO:0007422peripheral nervous system developmentIEA-
GO:0021675nerve developmentIEA-
GO:0051145smooth muscle cell differentiationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016023cytoplasmic membrane-bounded vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BDNFMGC34632brain-derived neurotrophic factor-HPRD7703225 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Reconstituted ComplexBioGRID8621424 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2-HPRD,BioGRID8621424 
NTRK3TRKC | gp145(trkC)neurotrophic tyrosine kinase, receptor, type 3Reconstituted ComplexBioGRID8621424 
-HPRD9488719 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_DN 3813All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_UP 3922All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D2 4130All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP 4533All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-200bc/429249255m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-21133139m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-221/22252591A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-369-3p85911Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37485921A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-41080861Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4484652m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-5391421481Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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