Gene Page: OAT

Summary
GeneID  4942
Symbol  OAT
Synonyms  DKFZp781A11155|HOGA
Description  ornithine aminotransferase (gyrate atrophy)
See related  HGNC:8091|MIM:258870|Ensembl:ENSG00000065154|HPRD:02021|
Locus tag  -
Gene type  protein-coding
Map location  10q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANXA70.910.88
PPAP2A0.880.88
CD550.880.86
RNF130.880.85
CPEB10.850.87
HTATIP20.850.82
ITM2B0.850.88
ME10.840.85
ATPAF10.820.79
ATP6V1E10.820.71
Top 10 negatively co-expressed genes
KIAA1949-0.69-0.70
SH3BP2-0.68-0.79
TUBB2B-0.68-0.73
SH2B2-0.65-0.77
MARCKSL1-0.65-0.64
ZNF311-0.65-0.61
DPYSL3-0.65-0.55
NKIRAS2-0.65-0.58
CCDC123-0.64-0.60
C6orf134-0.64-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004587ornithine-oxo-acid transaminase activityTASglutamate (GO term level: 6)3456579 
GO:0005515protein bindingIPI17353931 
GO:0016740transferase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007601visual perceptionTAS2793865 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionTAS2793865 
GO:0005759mitochondrial matrixNAS3456579 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C2orf18FLJ20555chromosome 2 open reading frame 18Two-hybridBioGRID16169070 
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6Affinity Capture-MSBioGRID17353931 
OATDKFZp781A11155 | HOGAornithine aminotransferase (gyrate atrophy)-HPRD9309222 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 1714All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
KIM_MYCL1_AMPLIFICATION_TARGETS_DN 2012All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_DN 7445All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_DN 6442All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES 4534All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN 4934All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
MIKHAYLOVA_OXIDATIVE_STRESS_RESPONSE_VIA_VHL_DN 65All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway


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