Gene Page: OXTR

Summary
GeneID  5021
Symbol  OXTR
Synonyms  OT-R
Description  oxytocin receptor
See related  HGNC:8529|MIM:167055|Ensembl:ENSG00000180914|HPRD:01328|
Locus tag  -
Gene type  protein-coding
Map location  3p25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.48 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CHN10.840.87
SYTL20.840.86
RGS40.830.86
CASQ10.830.76
GCNT40.810.81
KCNK10.800.82
HLF0.800.84
NRSN10.790.72
KIAA07480.790.84
GALNTL50.790.80
Top 10 negatively co-expressed genes
PKN1-0.54-0.63
PDE9A-0.54-0.68
FADS2-0.53-0.57
SH3BP2-0.53-0.69
BCL7C-0.52-0.69
KIAA1949-0.52-0.59
TUBB2B-0.52-0.66
SH2B2-0.51-0.67
TRAF4-0.51-0.66
KCTD11-0.51-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004990oxytocin receptor activityTAS10858434 
GO:0005000vasopressin receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007595lactationTAS1313946 
GO:0007565female pregnancyTAS1313946 
GO:0006936muscle contractionTAS1313946 
GO:0045777positive regulation of blood pressureIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS10858434 |10910058 
GO:0005887integral to plasma membraneTAS10858434 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2-HPRD11279203 
AVPADH | ARVP | AVP-NPII | AVRP | VParginine vasopressin-HPRD7921229 
GRK5GPRK5G protein-coupled receptor kinase 5Affinity Capture-WesternBioGRID10858434 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_DN 9153All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_DN 6644All SZGR genes in this pathway
LIU_TARGETS_OF_VMYB_VS_CMYB_DN 4330All SZGR genes in this pathway
MOROSETTI_FACIOSCAPULOHUMERAL_MUSCULAR_DISTROPHY_DN 126All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BALDWIN_PRKCI_TARGETS_UP 3526All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_12HR 3523All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_DN 7044All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_UP 5636All SZGR genes in this pathway
MATZUK_POST-IMPLANTATION_AND_POST-PARTUM 1413All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-294264331A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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