Gene Page: PEBP1

Summary
GeneID  5037
Symbol  PEBP1
Synonyms  HCNP|PBP|PEBP|RKIP
Description  phosphatidylethanolamine binding protein 1
See related  HGNC:8630|MIM:604591|Ensembl:ENSG00000089220|HPRD:06850|
Locus tag  -
Gene type  protein-coding
Map location  12q24.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTPN30.910.44
RGS160.900.46
GRID2IP0.900.31
FAM19A40.870.38
SUSD20.860.26
CHRNA30.850.49
AC010087.30.850.28
NOD20.840.24
TTC39A0.840.45
FAM180B0.840.21
Top 10 negatively co-expressed genes
WDR86-0.20-0.24
EMID1-0.19-0.26
C2orf84-0.18-0.39
PLEKHO1-0.18-0.10
FTHL16-0.17-0.31
NPAS1-0.16-0.11
MEIS3P2-0.160.16
AP002414.1-0.160.02
NR2C2AP-0.16-0.10
AL139099.2-0.15-0.17
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0008289lipid bindingIEA-
GO:0008429phosphatidylethanolamine bindingTAS7637590 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1RKIP interacts with GRK-2. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human GRK-2.BIND14654844 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1-HPRD,BioGRID10757792 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID11585904 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD,BioGRID10757792 
PEBP1HCNP | PBP | PEBP | RKIPphosphatidylethanolamine binding protein 1-HPRD9782050 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaPKCalpha interacts with and phosphorylates RKIP. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human PKCalpha.BIND14654844 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, deltaPKCdelta interacts with and phosphorylates RKIP. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human PKCdelta.BIND14654844 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD11853019 
RKIP interacts with Raf-1. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and Raf-1 from an unspecified species.BIND14654844 
Affinity Capture-Western
Reconstituted Complex		BioGRID10757792 
STC2STC-2 | STCRPstanniocalcin 2Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_AURORA_B_PATHWAY 3924All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN 11671All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
SCHUHMACHER_MYC_TARGETS_UP 8057All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MF_UP 4727All SZGR genes in this pathway
NAKAJIMA_MAST_CELL 4634All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_DN 5128All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
MATZUK_SPERMATOZOA 11477All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
JIANG_TIP30_TARGETS_DN 2414All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN 5639All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP 8451All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway


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