Gene Page: PAK2

Summary
GeneID  5062
Symbol  PAK2
Synonyms  PAK65|PAKgamma
Description  p21 protein (Cdc42/Rac)-activated kinase 2
See related  HGNC:8591|MIM:605022|Ensembl:ENSG00000180370|HPRD:05428|
Locus tag  -
Gene type  protein-coding
Map location  3q29
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0435 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NONO0.960.94
APEX10.960.94
KDM10.950.94
HNRNPL0.950.94
RBMX0.950.95
RBBP40.950.94
FUBP10.940.92
SMAD40.940.90
SF3B30.940.92
TH1L0.940.90
Top 10 negatively co-expressed genes
AF347015.31-0.71-0.88
AF347015.27-0.71-0.88
MT-CO2-0.70-0.88
C5orf53-0.69-0.76
AF347015.33-0.69-0.86
MT-CYB-0.68-0.87
HLA-F-0.68-0.76
AIFM3-0.68-0.77
AF347015.8-0.68-0.88
IFI27-0.66-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIDA11805089 
GO:0016740transferase activityIEA-
GO:0042802identical protein bindingIPI16837009 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEA-
GO:0006469negative regulation of protein kinase activityTAS10748018 
GO:0007165signal transductionTAS7744004 
GO:0006915apoptosisIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0046777protein amino acid autophosphorylationIDA11805089 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP15234964 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1-HPRD11956071 
ABI3NESH | SSH3BP3ABI family, member 3-HPRD,BioGRID11956071 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11121037 
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7-HPRD,BioGRID12226077 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD,BioGRID10320322 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2Reconstituted ComplexBioGRID12176041 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1Affinity Capture-MSBioGRID17353931 
GIT2CAT-2 | DKFZp686G01261 | KIAA0148 | MGC760G protein-coupled receptor kinase interacting ArfGAP 2Affinity Capture-MSBioGRID17353931 
MCM3HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFBminichromosome maintenance complex component 3Affinity Capture-MSBioGRID17353931 
MYH10MGC134913 | MGC134914 | NMMHCBmyosin, heavy chain 10, non-muscleAffinity Capture-MSBioGRID17353931 
MYL2CMH10 | DKFZp779C0562 | MLC2myosin, light chain 2, regulatory, cardiac, slow-HPRD,BioGRID10047984 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD11160719 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2hPAK65 autophosphorylates.BIND9151826 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID9535855 
RAC2EN-7 | Gx | HSPC022ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Reconstituted ComplexBioGRID12176041 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID12829691 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_MYC_PATHWAY 2522All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS 5834All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION 3226All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC 1411All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_VAV1_PATHWAY 1110All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR 3026All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
ZERBINI_RESPONSE_TO_SULINDAC_UP 96All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BALDWIN_PRKCI_TARGETS_UP 3526All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_UP 4928All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C4 1310All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_DN 2012All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_DN 4933All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-263513581A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-9829835m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.