Gene Page: GEMIN4

Summary
GeneID  50628
Symbol  GEMIN4
Synonyms  DKFZp434B131|DKFZp434D174|HC56|HCAP1|HHRF-1|p97
Description  gem (nuclear organelle) associated protein 4
See related  HGNC:15717|MIM:606969|Ensembl:ENSG00000179409|HPRD:07370|
Locus tag  -
Gene type  protein-coding
Map location  17p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11714716 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000387spliceosomal snRNP biogenesisEXP15130578 
GO:0006397mRNA processingIEA-
GO:0008380RNA splicingIEA-
GO:0006364rRNA processingTAS10725331 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10531003 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10531003 
GO:0005681spliceosomeIEA-
GO:0005730nucleolusTAS10725331 
GO:0005737cytoplasmTAS10725331 
GO:0030532small nuclear ribonucleoprotein complexTAS10725331 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARS2ASR2 | MGC126427arsenate resistance protein 2HCAP1 interacts with ARS2BIND12869526 
BRF2BRFU | FLJ11052 | TFIIIB50BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-likeAffinity Capture-MSBioGRID17353931 
CALCOCO2MGC17318 | NDP52calcium binding and coiled-coil domain 2HCAP1 interacts with NDP52BIND12869526 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4Affinity Capture-MSBioGRID17353931 
DDX20DKFZp434H052 | DP103 | GEMIN3DEAD (Asp-Glu-Ala-Asp) box polypeptide 20Affinity Capture-Western
Reconstituted Complex		BioGRID10725331 |11914277 
|12668731 
DHX9DDX9 | LKP | NDHII | RHADEAH (Asp-Glu-Ala-His) box polypeptide 9Affinity Capture-WesternBioGRID11149922 
EIF2C2AGO2 | MGC3183 | Q10eukaryotic translation initiation factor 2C, 2Affinity Capture-Western
Reconstituted Complex		BioGRID11914277 |14970384 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-WesternBioGRID11509230 
FIBPFGFIBP | FIBP-1fibroblast growth factor (acidic) intracellular binding proteinAffinity Capture-MSBioGRID17353931 
GAR1NOLA1GAR1 ribonucleoprotein homolog (yeast)Affinity Capture-WesternBioGRID11509230 
GEMIN5DKFZp586M1824 | MGC142174gem (nuclear organelle) associated protein 5-HPRD,BioGRID11714716 
GEMIN6FLJ23459gem (nuclear organelle) associated protein 6Affinity Capture-WesternBioGRID11748230 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1Affinity Capture-MSBioGRID17353931 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-MSBioGRID17353931 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-MSBioGRID17353931 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1-HPRD,BioGRID11522829 
LGALS3CBP35 | GAL3 | GALBP | GALIG | LGALS2 | MAC2lectin, galactoside-binding, soluble, 3-HPRD,BioGRID11522829 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-MSBioGRID17353931 
NFKBIL1IKBL | LST1 | NFKBILnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1Affinity Capture-MSBioGRID17353931 
PIAS3FLJ14651 | ZMIZ5protein inhibitor of activated STAT, 3HCAP1 interacts with PIAS3BIND12869526 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitAffinity Capture-WesternBioGRID12668731 
PPP4R2MGC131930protein phosphatase 4, regulatory subunit 2Affinity Capture-MS
Affinity Capture-Western		BioGRID12668731 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomericAffinity Capture-Western
Co-fractionation
Co-purification		BioGRID10942426 |12668731 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1Affinity Capture-MSBioGRID17353931 
-HPRD10725331 
SPRY1hSPRY1sprouty homolog 1, antagonist of FGF signaling (Drosophila)HCAP1 interacts with SPRY1BIND12869526 
STXBP3MUNC18-3 | MUNC18C | PSP | UNC-18Csyntaxin binding protein 3-HPRD12065586 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_METABOLISM_OF_NON_CODING_RNA 4929All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_DN 2315All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_UP 4732All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_17P13_DELETION 2115All SZGR genes in this pathway
GALE_APL_WITH_FLT3_MUTATED_UP 5635All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_DN 4117All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway


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