Gene Page: PCM1

Summary
GeneID  5108
Symbol  PCM1
Synonyms  PTC4
Description  pericentriolar material 1
See related  HGNC:8727|MIM:600299|Ensembl:ENSG00000078674|HPRD:02624|
Locus tag  -
Gene type  protein-coding
Map location  8p22-p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZC3H11A0.850.85
TAF10.850.85
LRCH30.850.87
ZSCAN290.850.85
ZNF3180.850.85
UBR50.850.86
CDC2L50.840.84
PTPN210.840.86
SETD50.840.84
ZFYVE260.830.86
Top 10 negatively co-expressed genes
IFI27-0.65-0.71
AF347015.31-0.63-0.70
MT-CO2-0.62-0.69
HIGD1B-0.61-0.70
MYL3-0.60-0.68
AF347015.27-0.60-0.66
AF347015.21-0.60-0.74
FXYD1-0.60-0.66
VAMP5-0.59-0.68
C5orf53-0.58-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI15107855 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042384cilium biogenesisIMP17574030 
GO:0042384cilium biogenesisTAS14520415 
GO:0051297centrosome organizationIMP17574030 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000242pericentriolar materialTAS8120099 
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmTAS8120099 
GO:0034451centriolar satelliteIDA17574030 
GO:0031513nonmotile primary ciliumIDA17574030 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI2ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIBabl interactor 2Two-hybridBioGRID16189514 
BBS4-Bardet-Biedl syndrome 4-HPRD,BioGRID15107855 
CCDC53CGI-116coiled-coil domain containing 53Two-hybridBioGRID16189514 
CEP72FLJ10565 | KIAA1519 | MGC5307centrosomal protein 72kDaTwo-hybridBioGRID16189514 
EPS8-epidermal growth factor receptor pathway substrate 8Two-hybridBioGRID16189514 
EXOC8EXO84 | Exo84p | SEC84exocyst complex component 8Two-hybridBioGRID16189514 
HAP1HAP2 | HIP5 | HLP | hHLP1huntingtin-associated protein 1-HPRD,BioGRID9361024 
ING5FLJ23842 | p28ING5inhibitor of growth family, member 5Two-hybridBioGRID16189514 
KIAA0368ECM29 | FLJ22036 | KIAA1962 | RP11-386D8.2KIAA0368Two-hybridBioGRID16189514 
KRT15CK15 | K15 | K1COkeratin 15Two-hybridBioGRID16189514 
KRT19CK19 | K19 | K1CS | MGC15366keratin 19Two-hybridBioGRID16189514 
PCNTKEN | MOPD2 | PCN | PCNT2 | PCNTB | PCTN2 | SCKL4pericentrin-HPRD,BioGRID11171385 
TTC8BBS8tetratricopeptide repeat domain 8-HPRD14520415 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_9 86All SZGR genes in this pathway
TOMLINS_METASTASIS_DN 2016All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
PARK_HSC_MARKERS 4431All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-49690961Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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