Gene Page: PCSK1

Summary
GeneID  5122
Symbol  PCSK1
Synonyms  BMIQ12|NEC1|PC1|PC3|SPC3
Description  proprotein convertase subtilisin/kexin type 1
See related  HGNC:8743|MIM:162150|Ensembl:ENSG00000175426|HPRD:01201|
Locus tag  -
Gene type  protein-coding
Map location  5q15-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BIN10.810.82
PIGZ0.770.81
KIFC20.760.82
SYNGR30.760.79
FBXO270.750.76
P2RX50.750.77
RHOF0.730.74
C19orf280.730.74
KCNQ40.730.78
AMDHD20.730.73
Top 10 negatively co-expressed genes
AF347015.21-0.41-0.19
RPS20-0.41-0.46
SNRPG-0.38-0.41
TPT1-0.38-0.35
CLIC1-0.36-0.45
RAB13-0.36-0.37
FAM60A-0.36-0.17
RPL24-0.36-0.35
NCAPG-0.36-0.15
RPL27-0.35-0.35
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisTAS9207799 
GO:0007267cell-cell signalingTAS9207799 
GO:0008152metabolic processTAS9207799 
GO:0043043peptide biosynthetic processISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005615extracellular spaceIDA8397508 
GO:0031410cytoplasmic vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID11113628 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-WesternBioGRID11113628 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS 1410All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 2115All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN 1611All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP 148All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K4ME3_AND_H3K27ME3 3834All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-186229322991Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-203.13093151Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-320212921351Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-410225722631Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-49421592165m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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