Gene Page: PCSK5

Summary
GeneID  5125
Symbol  PCSK5
Synonyms  PC5|PC6|PC6A|SPC6
Description  proprotein convertase subtilisin/kexin type 5
See related  HGNC:8747|MIM:600488|Ensembl:ENSG00000099139|HPRD:08985|
Locus tag  RP11-422N19.4
Gene type  protein-coding
Map location  9q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TUBA80.600.63
DTNBP10.590.47
PCP40.580.49
ECE20.570.59
BSPRY0.570.62
IKBKE0.570.44
KCTD170.560.38
HRH30.560.57
TMEM1730.550.46
CYB5R10.550.46
Top 10 negatively co-expressed genes
SH2B2-0.36-0.46
SOX12-0.35-0.39
PFN3-0.34-0.41
MEX3D-0.33-0.36
DSCC1-0.33-0.38
FOXO6-0.33-0.35
LENG9-0.32-0.31
AC018648.1-0.31-0.37
AIM2-0.31-0.39
ZNF775-0.31-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0008233peptidase activityIEA-
GO:0042277peptide bindingISS8940009 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002001renin secretion into blood streamIEP8901832 
GO:0001822kidney developmentIMP18519639 
GO:0001822kidney developmentISS8940009 
GO:0006465signal peptide processingIDA16912035 
GO:0007267cell-cell signalingTAS8901832 
GO:0009952anterior/posterior pattern formationIMP18519639 
GO:0007507heart developmentISS8940009 
GO:0007566embryo implantationISS8940009 
GO:0051605protein maturation via proteolysisIDA8901832 
GO:0042089cytokine biosynthetic processISS8940009 
GO:0019067viral assembly, maturation, egress, and releaseIEP8940009 
GO:0019067viral assembly, maturation, egress, and releaseISS8940009 
GO:0030323respiratory tube developmentISS8940009 
GO:0032455nerve growth factor processingEXP12787574 
GO:0035108limb morphogenesisISS8940009 
GO:0043043peptide biosynthetic processIDA8901832 
GO:0048566embryonic gut developmentIMP18519639 
GO:0048566embryonic gut developmentISS8940009 
GO:0048706embryonic skeletal system developmentIMP18519639 
GO:0048706embryonic skeletal system developmentISS8940009 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusISS-
GO:0005796Golgi lumenEXP8615794 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS8940009 
GO:0030141secretory granuleISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AMHMIF | MISanti-Mullerian hormone-HPRD8755541 
APPBP2HS.84084 | KIAA0228 | PAT1amyloid beta precursor protein (cytoplasmic tail) binding protein 2Two-hybridBioGRID16189514 
RENFLJ10761renin-HPRD8901832 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_UP 2618All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP 1810All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MS_UP 4832All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_10HR_UP 5438All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13926321Ahsa-miR-139brainUCUACAGUGCACGUGUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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