Gene Page: ENPP1

Summary
GeneID  5167
Symbol  ENPP1
Synonyms  M6S1|NPP1|NPPS|PC-1|PCA1|PDNP1
Description  ectonucleotide pyrophosphatase/phosphodiesterase 1
See related  HGNC:3356|MIM:173335|Ensembl:ENSG00000197594|HPRD:01415|
Locus tag  -
Gene type  protein-coding
Map location  6q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FGFR40.730.51
HPX0.700.49
KIAA16830.690.52
PLA2G4B0.690.50
IL3RA0.670.50
JMJD7-PLA2G4B0.670.50
CSAD0.670.43
AC008403.10.670.45
CCDC840.670.51
CCNL20.670.44
Top 10 negatively co-expressed genes
PLA2G4A-0.40-0.46
RGS5-0.40-0.46
CYCS-0.39-0.42
ABCG2-0.39-0.43
NAPB-0.38-0.39
C6orf106-0.38-0.42
TPMT-0.38-0.44
OSTF1-0.37-0.41
CCDC25-0.37-0.41
GHITM-0.37-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0003676nucleic acid bindingIEA-
GO:0005158insulin receptor bindingIDA7830796 
GO:0005515protein bindingIPI11289049 
GO:0005524ATP bindingIDA7830796 
GO:0004551nucleotide diphosphatase activityEXP8001561 
GO:0004551nucleotide diphosphatase activityIEA-
GO:0004519endonuclease activityIEA-
GO:0004528phosphodiesterase I activityIEA-
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityIDA7830796 
GO:0046872metal ion bindingIEA-
GO:00506563'-phosphoadenosine 5'-phosphosulfate bindingIC7830796 
GO:0047429nucleoside-triphosphate diphosphatase activityIDA7830796 |10513816 |11159191 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001503ossificationIEA-
GO:0006091generation of precursor metabolites and energyIDA12746903 
GO:0008152metabolic processIEA-
GO:0006796phosphate metabolic processIDA10513816 |11159191 
GO:0009143nucleoside triphosphate catabolic processIDA10513816 
GO:0030500regulation of bone mineralizationIC10513816 
GO:0030505inorganic diphosphate transportIDA10513816 
GO:0032869cellular response to insulin stimulusIDA7830796 |17849011 
GO:0030279negative regulation of ossificationIEA-
GO:0030308negative regulation of cell growthIDA17849011 
GO:0030730sequestering of triacylglycerolIDA17849011 
GO:0030643cellular phosphate ion homeostasisIDA11159191 
GO:0031953negative regulation of protein amino acid autophosphorylationIDA11289049 
GO:0045599negative regulation of fat cell differentiationIDA17849011 
GO:0045719negative regulation of glycogen biosynthetic processIDA11289049 
GO:0046849bone remodelingIEA-
GO:0046325negative regulation of glucose importIDA17849011 
GO:0046627negative regulation of insulin receptor signaling pathwayIDA7830796 |17849011 
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic processIDA7830796 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005615extracellular spaceIDA11159191 
GO:0016021integral to membraneTAS1315502 
GO:0009986cell surfaceIDA10513816 
GO:0005886plasma membraneEXP8001561 
GO:0005886plasma membraneIDA10513816 
GO:0016323basolateral plasma membraneNAS9553761 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID10615944 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_STARCH_AND_SUCROSE_METABOLISM 5233All SZGR genes in this pathway
KEGG_RIBOFLAVIN_METABOLISM 1611All SZGR genes in this pathway
KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM 2416All SZGR genes in this pathway
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS 169All SZGR genes in this pathway
REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 5136All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_UP 2614All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
JAEGER_METASTASIS_UP 4423All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP 11966All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP 2616All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP 9760All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
TRAYNOR_RETT_SYNDROM_DN 1914All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN 13588All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_DN 4628All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P7 9052All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
HUANG_FOXA2_TARGETS_UP 4528All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway


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