Gene Page: GHRL

Summary
GeneID  51738
Symbol  GHRL
Synonyms  MTLRP|obestatin
Description  ghrelin/obestatin prepropeptide
See related  HGNC:18129|MIM:605353|Ensembl:ENSG00000157017|HPRD:05638|
Locus tag  -
Gene type  protein-coding
Map location  3p26-p25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016608growth hormone-releasing hormone activityIEA-
GO:0016608growth hormone-releasing hormone activityISS10604470 
GO:0031768ghrelin receptor bindingISS-
GO:0030296protein tyrosine kinase activator activityIMP15350694 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051965positive regulation of synaptogenesisIDASynap (GO term level: 10)16491079 
GO:0051965positive regulation of synaptogenesisIEASynap (GO term level: 10)-
GO:0060079regulation of excitatory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0016358dendrite developmentIDAneurite, dendrite (GO term level: 11)16491079 
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0000187activation of MAPK activityIMP15350694 
GO:0001937negative regulation of endothelial cell proliferationIDA15572208 
GO:0030252growth hormone secretionTAS16511605 
GO:0007204elevation of cytosolic calcium ion concentrationISS-
GO:0007186G-protein coupled receptor protein signaling pathwayISS10604470 
GO:0006006glucose metabolic processNAS17392603 
GO:0008343adult feeding behaviorISS-
GO:0009755hormone-mediated signalingTAS16511605 
GO:0008154actin polymerization or depolymerizationIDA15232612 
GO:0043066negative regulation of apoptosisIDA15158140 
GO:0032024positive regulation of insulin secretionISS-
GO:0032100positive regulation of appetiteIEA-
GO:0032100positive regulation of appetiteISS-
GO:0016525negative regulation of angiogenesisNAS15572208 
GO:0040013negative regulation of locomotionIEA-
GO:0042127regulation of cell proliferationIDA15564328 |16394173 
GO:0051216cartilage developmentNAS15576457 
GO:0040018positive regulation of multicellular organism growthIC16511605 
GO:0032691negative regulation of interleukin-1 beta productionIDA15232612 
GO:0043400cortisol secretionNAS17201814 
GO:0042536negative regulation of tumor necrosis factor biosynthetic processIDA15232612 
GO:0050728negative regulation of inflammatory responseIDA15232612 
GO:0043627response to estrogen stimulusIDA15292338 
GO:0046676negative regulation of insulin secretionIEA-
GO:0046697decidualizationIDA17494105 
GO:0045409negative regulation of interleukin-6 biosynthetic processIDA15232612 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonIDAneuron, axon, Neurotransmitter (GO term level: 6)17113048 
GO:0005576extracellular regionIDA17392603 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA15039149 |15531532 
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGRPAGRT | ART | ASIP2 | MGC118963agouti related protein homolog (mouse)-HPRD11196643 
GHRHRGHRFR | GHRHRpsv | GRFRgrowth hormone releasing hormone receptor-HPRD,BioGRID10461027 
GHSR-growth hormone secretagogue receptor-HPRD,BioGRID10604470 |11227737 
LEPFLJ94114 | OB | OBSleptin-HPRD11196643 
MLNRGPR38 | MTLR1motilin receptor-HPRD,BioGRID12606621 
NPYPYY4neuropeptide Y-HPRD11196643 |12663466 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN 1611All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_DN 3524All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
ROLEF_GLIS3_TARGETS 3729All SZGR genes in this pathway


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