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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PIN1

Summary

GeneID

5300

Symbol

PIN1

Synonyms

DOD|UBL5

Description

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Locus tag

Gene type

protein-coding

Map location

19p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0573

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PTPN3

0.87

0.59

PTPN4

0.86

0.81

AKAP2

0.85

0.74

MCF2

0.85

0.62

FAM19A4

0.84

0.33

RORA

0.84

0.47

EPN3

0.84

0.45

RASSF3

0.84

0.49

CHRNA3

0.83

0.53

SLC17A6

0.83

0.69

Top 10 negatively co-expressed genes

C16orf74

-0.32

-0.53

RGS20

-0.32

-0.48

C1orf61

-0.31

-0.61

CXCL14

-0.31

-0.48

OAF

-0.31

-0.47

CSAG1

-0.30

-0.50

CLDN10

-0.29

-0.47

AF347015.21

-0.29

-0.54

EIF4EBP3

-0.29

-0.53

VAMP5

-0.29

-0.54

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

IEA

GO:0005515

protein binding

IPI

11470801

GO:0016853

isomerase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006457

protein folding

IEA

GO:0007049

cell cycle

IEA

GO:0007088

regulation of mitosis

TAS

10391244

GO:0042127

regulation of cell proliferation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

TAS

8606777

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD	11988841
BCL2	Bcl-2	B-cell CLL/lymphoma 2	Affinity Capture-Western	BioGRID	11326318
CCNB1	CCNB	cyclin B1	-	HPRD	9499405
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	PIN1 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human PIN1 and Cyclin D1 from an unspecified species.	BIND	11805292
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	11774038
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD	9482729 \|9499405 \|10037602\|9499405 \|10037602
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD,BioGRID	9499405 \|10037602
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	-	HPRD,BioGRID	9499405 \|10939594
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	Pin1 interacts with Cdc27.	BIND	9499405
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	-	HPRD	11575923
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	11940573
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	11940573
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD	11940573
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD,BioGRID	11533658
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	12881709
DDX24	-	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	Two-hybrid	BioGRID	16169070
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	Two-hybrid	BioGRID	16189514
GPAA1	GAA1 \| hGAA1	glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)	Two-hybrid	BioGRID	16169070
HNRNPC	C1 \| C2 \| HNRNP \| HNRPC \| MGC104306 \| MGC105117 \| MGC117353 \| MGC131677 \| SNRPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Two-hybrid	BioGRID	16189514
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	11432833
KIF20B	DKFZp434B0435 \| DKFZp434P0810 \| KRMP1 \| MPHOSPH1 \| MPP-1 \| MPP1	kinesin family member 20B	-	HPRD,BioGRID	11470801
KLHL20	KHLHX \| KLEIP \| KLHLX \| RP3-383J4.3	kelch-like 20 (Drosophila)	Two-hybrid	BioGRID	16169070
LEPR	CD295 \| OBR	leptin receptor	Two-hybrid	BioGRID	16169070
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD,BioGRID	10391244
MDFI	I-MF \| I-mfa	MyoD family inhibitor	Two-hybrid	BioGRID	16189514
MYT1	C20orf36 \| MTF1 \| MYTI \| PLPB1	myelin transcription factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10504341
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	11356192
NONO	NMT55 \| NRB54 \| P54 \| P54NRB	non-POU domain containing, octamer-binding	Two-hybrid	BioGRID	16189514
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	-	HPRD,BioGRID	9499405 \|10504341
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	Pin1 interacts with phosphorylated Myt1.	BIND	10504341
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	-	HPRD,BioGRID	9499405
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	Pin1 interacts with PLK1.	BIND	9499405
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	-	HPRD	10932246
POLR2A		polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Affinity Capture-Western	BioGRID	10393805
PTOV1	ACID2 \| DKFZp586I111 \| MGC71475	prostate tumor overexpressed 1	Two-hybrid	BioGRID	16169070
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD	9499405
RAB4A	HRES-1/RAB4 \| RAB4	RAB4A, member RAS oncogene family	-	HPRD,BioGRID	10888662
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Raf-1 interacts with Pin1. This interaction was modelled on a demonstrated interaction between human Raf-1 and Pin1 from monkey and unspecified species.	BIND	15664191
RAI1	DKFZp434A139 \| KIAA1820 \| MGC12824 \| SMCR \| SMS	retinoic acid induced 1	Two-hybrid	BioGRID	16189514
RBBP8	CTIP \| RIM	retinoblastoma binding protein 8	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	Two-hybrid	BioGRID	16169070
SUPT5H	FLJ34157 \| SPT5 \| SPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	-	HPRD,BioGRID	11575923
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	11940573
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	12388558 \|12397362
TP73	P73	tumor protein p73	Pin1 interacts with phosphorylated p73-alpha	BIND	15175157
TP73	P73	tumor protein p73	Pin1 interacts with p73-beta.	BIND	15175157
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
TSC22D4	THG-1 \| THG1	TSC22 domain family, member 4	Two-hybrid	BioGRID	16189514
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Affinity Capture-MS	BioGRID	17353931
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	Affinity Capture-Western Far Western	BioGRID	9499405
ZCCHC10	FLJ20094	zinc finger, CCHC domain containing 10	Two-hybrid	BioGRID	16169070
ZMIZ2	DKFZp761I2123 \| KIAA1886 \| ZIMP7 \| hZIMP7	zinc finger, MIZ-type containing 2	Two-hybrid	BioGRID	16189514

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY	71	51	All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY	34	28	All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY	34	28	All SZGR genes in this pathway
PID_P73PATHWAY	79	59	All SZGR genes in this pathway
PID_MYC_PATHWAY	25	22	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY	59	50	All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	66	45	All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING	159	116	All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING	31	19	All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS	73	57	All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM	279	178	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN	241	146	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN	260	143	All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER	22	19	All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP	380	213	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP	479	299	All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN	121	79	All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN	16	12	All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN	52	33	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP	428	266	All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE	246	153	All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP	425	253	All SZGR genes in this pathway
MATZUK_SPERMATOGONIA	24	17	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN	146	90	All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP	194	133	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-200bc/429	111	117	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.