Gene Page: PLP1

Summary
GeneID  5354
Symbol  PLP1
Synonyms  MMPL|PLP|PLP/DM20|PMD|SPG2
Description  proteolipid protein 1
See related  HGNC:9086|MIM:300401|Ensembl:ENSG00000123560|HPRD:02321|
Locus tag  -
Gene type  protein-coding
Map location  Xq22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityTAS2479017 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0022010myelination in the central nervous systemIEAneuron, axon, oligodendrocyte, dendrite (GO term level: 14)-
GO:0008366axon ensheathmentTASneuron, axon (GO term level: 12)2479017 
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)2479017 
GO:0048469cell maturationIEA-
GO:0042759long-chain fatty acid biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043209myelin sheathIEAneuron, axon, oligodendrocyte, Glial (GO term level: 7)-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MAGGMA | S-MAG | SIGLEC-4A | SIGLEC4Amyelin associated glycoprotein-HPRD12237860 
MBPMGC99675myelin basic protein-HPRD,BioGRID2467009 |6083474 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_UP 4526All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_DN 3927All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION 4029All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
RAMASWAMY_METASTASIS_DN 6147All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_UP 1816All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_PTEN_TARGETS_UP 189All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14041471Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-146201020161Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-18611301136m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-26111117m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-29986992m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-36119081914m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-362572578m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-54320062012m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.