Gene Page: ATP7A

Summary
GeneID  538
Symbol  ATP7A
Synonyms  FLJ17790|MK|MNK
Description  ATPase, Cu++ transporting, alpha polypeptide
See related  HGNC:869|MIM:300011|Ensembl:ENSG00000165240|HPRD:02054|
Locus tag  RP3-465G10.1
Gene type  protein-coding
Map location  Xq13.2-q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 10 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004008copper-exporting ATPase activityIEA-
GO:0004008copper-exporting ATPase activityISS-
GO:0005375copper ion transmembrane transporter activityIEA-
GO:0005375copper ion transmembrane transporter activityISS-
GO:0005507copper ion bindingIDA15670166 
GO:0005507copper ion bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingTAS9817923 
GO:0016787hydrolase activityIEA-
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA-
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismIEA-
GO:0016532superoxide dismutase copper chaperone activityISS-
GO:0015097mercury ion transmembrane transporter activityIEA-
GO:0032767copper-dependent protein bindingIPI10497213 
GO:0046872metal ion bindingIEA-
GO:0046873metal ion transmembrane transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0021702cerebellar Purkinje cell differentiationISSneuron, GABA, Brain (GO term level: 15)-
GO:0021954central nervous system neuron developmentISSneuron (GO term level: 10)-
GO:0021860pyramidal neuron developmentISSneuron, Brain (GO term level: 12)-
GO:0043526neuroprotectionISSneuron (GO term level: 9)-
GO:0048812neurite morphogenesisISSneuron, axon, neurite, dendrite (GO term level: 11)-
GO:0042428serotonin metabolic processISSserotonin, Neurotransmitter (GO term level: 8)-
GO:0042417dopamine metabolic processISSNeurotransmitter, dopamine (GO term level: 8)-
GO:0042415norepinephrine metabolic processISSNeurotransmitter (GO term level: 8)-
GO:0001568blood vessel developmentISS-
GO:0002082regulation of oxidative phosphorylationISS-
GO:0001974blood vessel remodelingISS-
GO:0030001metal ion transportIEA-
GO:0008152metabolic processIEA-
GO:0010273detoxification of copper ionISS-
GO:0007626locomotory behaviorISS-
GO:0006825copper ion transportIEA-
GO:0006811ion transportIEA-
GO:0006810transportIEA-
GO:0007005mitochondrion organizationISS-
GO:0006878cellular copper ion homeostasisIMP16397091 
GO:0006568tryptophan metabolic processISS-
GO:0015694mercury ion transportIEA-
GO:0015677copper ion importISS-
GO:0042093T-helper cell differentiationISS-
GO:0018205peptidyl-lysine modificationISS-
GO:0031069hair follicle morphogenesisISS-
GO:0043473pigmentationISS-
GO:0030199collagen fibril organizationISS-
GO:0051216cartilage developmentISS-
GO:0051353positive regulation of oxidoreductase activityIDA11092760 
GO:0042414epinephrine metabolic processISS-
GO:0048251elastic fiber assemblyISS-
GO:0048286alveolus developmentISS-
GO:0019430removal of superoxide radicalsISS-
GO:0043588skin developmentISS-
GO:0048553negative regulation of metalloenzyme activityISS-
GO:0048554positive regulation of metalloenzyme activityISS-
GO:0051542elastin biosynthetic processISS-
GO:0060003copper ion exportISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaISSaxon, dendrite (GO term level: 4)-
GO:0043005neuron projectionISSneuron, axon, neurite, dendrite (GO term level: 5)-
GO:0005794Golgi apparatusIDA9467005 
GO:0005802trans-Golgi networkIDA8943055 |12812980 
GO:0005737cytoplasmIEA-
GO:0005770late endosomeIDA8943055 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA12812980 
GO:0048471perinuclear region of cytoplasmIDA8943055 |10567439 |16397091 
GO:0016323basolateral plasma membraneIDA16397091 
GO:0030140trans-Golgi network transport vesicleIMP9817923 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATOX1ATX1 | HAH1 | MGC138453 | MGC138455ATX1 antioxidant protein 1 homolog (yeast)-HPRD,BioGRID10497213 |10557326 
CPCP-2ceruloplasmin (ferroxidase)-HPRD11040994 
GLRXGRX | GRX1 | MGC117407glutaredoxin (thioltransferase)Affinity Capture-Western
Two-hybrid		BioGRID16884690 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 3421All SZGR genes in this pathway
REACTOME_ION_CHANNEL_TRANSPORT 5542All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP 13794All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_UP 11668All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_UV 6243All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
KANG_CISPLATIN_RESISTANCE_UP 1911All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 225124All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_UP 6141All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_UP 3827All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES 275155All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20633633369m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.1522528m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5065215281A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-148/15236431A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-182345934651Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-20520552061m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2236676741A,m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-29206020661Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-5p196619721Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-421332433301Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-9293029361Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96345934651Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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