Gene Page: POMC

Summary
GeneID  5443
Symbol  POMC
Synonyms  ACTH|CLIP|LPH|MSH|NPP|POC
Description  proopiomelanocortin
See related  HGNC:9201|MIM:176830|Ensembl:ENSG00000115138|HPRD:01462|
Locus tag  -
Gene type  protein-coding
Map location  2p23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM19A10.780.84
RND10.720.77
TCEAL10.720.80
PRPS20.720.75
AC012652.10.710.75
PVRL30.690.74
FABP30.680.75
TM6SF10.670.79
IL12RB20.670.77
R3HDM10.670.75
Top 10 negatively co-expressed genes
SORBS3-0.51-0.56
PLXNB1-0.49-0.49
CASKIN2-0.45-0.47
NFKB2-0.42-0.51
TRIP6-0.42-0.49
EML3-0.41-0.43
MAPKAPK3-0.41-0.45
ACP6-0.41-0.43
SLC9A3R1-0.40-0.43
SLC2A4RG-0.40-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005179hormone activityTAS9620771 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0008217regulation of blood pressureIEA-
GO:0007267cell-cell signalingTAS9620771 
GO:0006091generation of precursor metabolites and energyTAS9620771 
GO:0007165signal transductionTAS9620771 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS9620771 
GO:0030141secretory granuleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HLA-DRB3HLA-DR3B | MGC117330major histocompatibility complex, class II, DR beta 3-HPRD,BioGRID7477400 
MC1RMGC14337 | MSH-R | SHEP2melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)-HPRD,BioGRID10942578 |11041375 
MC2RACTHR | MGC125798melanocortin 2 receptor (adrenocorticotropic hormone)-HPRD12213892 
MC4RMGC126851 | MGC138197melanocortin 4 receptor-HPRD,BioGRID11101306 |12165561 
MC5R-melanocortin 5 receptor-HPRD8185570 |11606131 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID2475499 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 3523All SZGR genes in this pathway
REACTOME_ANDROGEN_BIOSYNTHESIS 108All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE 5134All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
REACTOME_ENDOGENOUS_STEROLS 1510All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS 1410All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_STEROID_HORMONES 2921All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_UP 4629All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN 4831All SZGR genes in this pathway
MCGARVEY_SILENCED_BY_METHYLATION_IN_COLON_CANCER 4229All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway


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