Gene Page: PPP2R1A

Summary
GeneID  5518
Symbol  PPP2R1A
Synonyms  MGC786|PR65A
Description  protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
See related  HGNC:9302|MIM:605983|Ensembl:ENSG00000105568|HPRD:16184|
Locus tag  -
Gene type  protein-coding
Map location  19q13.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4639 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EIF4ENIF10.920.92
C6orf1680.920.92
TRPC4AP0.910.91
RTN10.910.90
CS0.910.91
KIFAP30.910.92
VPS26B0.900.91
EFTUD20.900.92
RUSC10.900.92
AP1M10.900.90
Top 10 negatively co-expressed genes
AF347015.31-0.84-0.86
MT-CO2-0.83-0.86
AF347015.8-0.82-0.87
AF347015.33-0.82-0.84
AF347015.27-0.81-0.85
MT-CYB-0.81-0.84
AF347015.15-0.79-0.84
AF347015.2-0.79-0.85
AF347015.26-0.78-0.85
FXYD1-0.78-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003823antigen bindingIPI9847399 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9847399 
GO:0008601protein phosphatase type 2A regulator activityTAS11007961 
GO:0046982protein heterodimerization activityIPI9847399 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000188inactivation of MAPK activityNAS11007961 
GO:0008380RNA splicingNAS11007961 
GO:0006461protein complex assemblyTAS9989501 
GO:0006470protein amino acid dephosphorylationTAS11007961 
GO:0010033response to organic substanceNAS11007961 
GO:0006275regulation of DNA replicationNAS11007961 
GO:0006917induction of apoptosisTAS11007961 
GO:0006672ceramide metabolic processNAS11007961 
GO:0030111regulation of Wnt receptor signaling pathwayNAS11007961 
GO:0030155regulation of cell adhesionNAS11007961 
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinNAS11007961 
GO:0040008regulation of growthNAS11360189 
GO:0019932second-messenger-mediated signalingNAS11007961 
GO:0030308negative regulation of cell growthNAS11007961 
GO:0045595regulation of cell differentiationNAS11360189 
GO:0045449regulation of transcriptionNAS11007961 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000159protein phosphatase type 2A complexTAS11007961 
GO:0005829cytosolIEA-
GO:0005829cytosolTAS11007961 
GO:0005625soluble fractionNAS11007961 
GO:0005634nucleusNAS11007961 
GO:0005739mitochondrionNAS11007961 
GO:0016020membraneNAS11007961 
GO:0015630microtubule cytoskeletonNAS11007961 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARIH2ARI2 | FLJ10938 | FLJ33921 | TRIAD1ariadne homolog 2 (Drosophila)Two-hybridBioGRID16169070 
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1Affinity Capture-MSBioGRID17353931 
CTTNBP2C7orf8 | CORTBP2 | FLJ34229 | KIAA1758 | MGC104579 | Orf4cortactin binding protein 2Affinity Capture-MSBioGRID18782753 
CTTNBP2NLDKFZp547A023 | FLJ13278CTTNBP2 N-terminal likeAffinity Capture-MS
Affinity Capture-Western		BioGRID18782753 
FAM40AFLJ14743 | KIAA1761 | MGC148091 | RP4-773N10.1family with sequence similarity 40, member AAffinity Capture-MS
Affinity Capture-Western		BioGRID18782753 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12Galpha12 interacts with Aalpha. This interaction was modelled on a demonstrated interaction between mouse Galpha12 and human Aalpha.BIND15525651 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD10862698 
HSF2MGC117376 | MGC156196 | MGC75048heat shock transcription factor 2-HPRD10224043 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
IPO9DKFZp761M1547 | FLJ10402 | Imp9importin 9-HPRD12670497 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)Affinity Capture-MSBioGRID18782753 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD14743216 
PDCD10CCM3 | MGC1212 | MGC24477 | TFAR15programmed cell death 10Affinity Capture-MSBioGRID18782753 
PPFIA1FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1Affinity Capture-MSBioGRID18782753 
PPFIA2FLJ41378 | MGC132572protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2Affinity Capture-MSBioGRID18782753 
PPME1FLJ22226 | PME-1protein phosphatase methylesterase 1Affinity Capture-MSBioGRID18782753 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
A-alpha subunit interacts with C-alpha subunit of PP2A.BIND12370081 
PPP2CBPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
PPP2R1BMGC26454 | PR65Bprotein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoformAffinity Capture-MSBioGRID18782753 
PPP2R2AB55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55Aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
PPP2R2CB55-GAMMA | IMYPNO | IMYPNO1 | MGC33570 | PR52 | PR55Gprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoformAffinity Capture-MSBioGRID18782753 
PPP2R2DMDS026protein phosphatase 2, regulatory subunit B, delta isoformAffinity Capture-MSBioGRID18782753 
PPP2R3BNY-REN-8 | PPP2R3L | PPP2R3LY | PR48protein phosphatase 2 (formerly 2A), regulatory subunit B'', betaAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID12370081 |18782753 
PPP2R5CB56G | MGC23064 | PR61Gprotein phosphatase 2, regulatory subunit B', gamma isoformAffinity Capture-MSBioGRID18782753 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformAffinity Capture-MSBioGRID18782753 
PPP2R5E-protein phosphatase 2, regulatory subunit B', epsilon isoformAffinity Capture-MSBioGRID18782753 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitAffinity Capture-MSBioGRID17353931 |18715871 
PPP5CFLJ36922 | PP5 | PPP5protein phosphatase 5, catalytic subunit-HPRD11504734 
RP5-1000E10.4DKFZp686A0768 | FLJ21168 | SIKEsuppressor of IKK epsilonAffinity Capture-MSBioGRID18782753 
RP6-213H19.1MASK | MST4serine/threonine protein kinase MST4Affinity Capture-MSBioGRID18782753 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 |18782753 
STK25DKFZp686J1430 | SOK1 | YSK1serine/threonine kinase 25 (STE20 homolog, yeast)Affinity Capture-MSBioGRID18782753 
STRNMGC125642 | SG2NAstriatin, calmodulin binding proteinAffinity Capture-MSBioGRID18782753 
STRN3SG2NAstriatin, calmodulin binding protein 3Affinity Capture-MSBioGRID18782753 
STRN4FLJ35594 | ZIN | zinedinstriatin, calmodulin binding protein 4Affinity Capture-MSBioGRID18782753 
TRAF3IP3DJ434O14.3 | FLJ44151 | MGC117354 | MGC163289 | T3JAMTRAF3 interacting protein 3Affinity Capture-MSBioGRID18782753 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
PID_ATR_PATHWAY 3925All SZGR genes in this pathway
PID_PLK1_PATHWAY 4625All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 1611All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 149All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERKS_ARE_INACTIVATED 129All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_GLYCOLYSIS 2918All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_DARPP_32_EVENTS 2520All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_CTLA4_INHIBITORY_SIGNALING 2115All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_PLATELET_SENSITIZATION_BY_LDL 169All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 136All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_GLUCOSE_METABOLISM 6942All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 17657All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
CREIGHTON_AKT1_SIGNALING_VIA_MTOR_DN 2316All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_DN 7657All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G4 2115All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN 9671All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_DN 3020All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
GRADE_METASTASIS_DN 4531All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497290296m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-338171Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.