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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PPP3R1

Summary

GeneID

5534

Symbol

PPP3R1

Synonyms

CALNB1|CNB|CNB1

Description

protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform

Locus tag

Gene type

protein-coding

Map location

2p15

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.4486

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SLC27A4

0.91

0.90

ENO2

0.90

0.88

SV2A

0.88

0.86

KIAA0319L

0.87

0.84

MAGEE1

0.87

0.89

ABCG4

0.87

GBA2

0.86

0.83

GPI

0.86

0.83

ATP6AP1

0.86

0.85

ABCF3

0.86

0.82

Top 10 negatively co-expressed genes

AF347015.21

-0.64

-0.50

AF347015.31

-0.59

-0.46

MT-CO2

-0.57

-0.45

GNG11

-0.57

-0.50

AF347015.2

-0.56

-0.39

AF347015.8

-0.56

-0.42

AF347015.18

-0.55

-0.40

HIGD1B

-0.55

-0.43

C1orf54

-0.54

-0.52

AP002478.3

-0.54

-0.48

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005509

calcium ion binding

NAS

2558868

GO:0005515

protein binding

IPI

8524402

GO:0005517

calmodulin inhibitor activity

NAS

2558868

GO:0004723

calcium-dependent protein serine/threonine phosphatase activity

NAS

2558868

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008633

activation of pro-apoptotic gene products

EXP

15231831

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

10195903

GO:0005955

calcineurin complex

NAS

2558868

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CABP1	CALBRAIN \| HCALB_BR	calcium binding protein 1	Reconstituted Complex	BioGRID	11108966
CABP2	-	calcium binding protein 2	-	HPRD,BioGRID	11108966
CABP5	-	calcium binding protein 5	Reconstituted Complex	BioGRID	11108966
CRTC1	FLJ14027 \| KIAA0616 \| MECT1 \| TORC1 \| WAMTP1	CREB regulated transcription coactivator 1	TORC1 interacts with calcineurin. This interaction was modeled on a demonstrated interaction between human TORC1 and bovine calcineurin.	BIND	15589160
FKBP1A	FKBP-12 \| FKBP1 \| FKBP12 \| FKBP12C \| PKC12 \| PKCI2 \| PPIASE	FK506 binding protein 1A, 12kDa	-	HPRD	7541044
PPIA	CYPA \| CYPH \| MGC117158 \| MGC12404 \| MGC23397	peptidylprolyl isomerase A (cyclophilin A)	-	HPRD,BioGRID	12218175

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS	114	79	All SZGR genes in this pathway
KEGG_APOPTOSIS	88	62	All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY	76	53	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	75	56	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE	169	110	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
PID_IL12_2PATHWAY	63	54	All SZGR genes in this pathway
PID_NFAT_3PATHWAY	54	47	All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY	29	23	All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY	65	56	All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY	33	29	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING	78	56	All SZGR genes in this pathway
REACTOME_DARPP_32_EVENTS	25	20	All SZGR genes in this pathway
REACTOME_APOPTOSIS	148	94	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS	17	12	All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS	30	21	All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP	372	227	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP	32	25	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN	1375	806	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
KARAKAS_TGFB1_SIGNALING	18	15	All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION	475	313	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL	293	160	All SZGR genes in this pathway
LU_AGING_BRAIN_DN	153	120	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP	178	111	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN	165	106	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP	148	96	All SZGR genes in this pathway
MATZUK_MEIOTIC_AND_DNA_REPAIR	39	26	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP	83	63	All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN	87	66	All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN	88	68	All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP	49	35	All SZGR genes in this pathway
LU_EZH2_TARGETS_UP	295	155	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	2070	2076	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1505	1511	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1505	1511	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	154	160	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	154	160	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	2069	2076	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d	193	200	1A,m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	2010	2016	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	1642	1649	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-190	230	236	1A	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-194	1826	1832	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-204/211	248	255	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	248	255	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-221/222	189	195	1A	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
				hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-26	386	392	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	386	392	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	110	116	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	110	116	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	1607	1614	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-342	1528	1534	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-410	329	335	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-433-3p	139	145	1A	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-485-3p	2073	2080	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-5p	135	141	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-493-5p	486	492	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	1824	1830	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-495	1824	1830	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	319	325	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	319	325	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-505	2007	2013	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-543	1657	1663	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	1657	1663	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520	192	198	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	1643	1649	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	1643	1649	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.