Gene Page: CDK5RAP2

Summary
GeneID  55755
Symbol  CDK5RAP2
Synonyms  C48|Cep215|DKFZp686B1070|DKFZp686D1070|KIAA1633|MCPH3
Description  CDK5 regulatory subunit associated protein 2
See related  HGNC:18672|MIM:608201|Ensembl:ENSG00000136861|HPRD:09740|
Locus tag  RP11-412P1.1
Gene type  protein-coding
Map location  9q33.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LRRC40.800.81
SLITRK10.790.84
TMEM1780.780.82
ITPK10.780.78
LARGE0.780.81
A2BP10.770.78
BCAS30.770.79
CDH220.770.80
SH3GL20.770.81
SIPA1L10.760.78
Top 10 negatively co-expressed genes
DBI-0.54-0.60
AF347015.21-0.49-0.42
RAB34-0.49-0.55
RHOC-0.49-0.53
AP002478.3-0.49-0.50
PSME2-0.48-0.50
NSBP1-0.47-0.51
GNG11-0.47-0.47
AF347015.18-0.46-0.42
AL139819.3-0.46-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042808neuronal Cdc2-like kinase bindingIPIneuron (GO term level: 7)10721722 
GO:0008017microtubule bindingIDA14654843 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentNASBrain (GO term level: 7)10915792 
GO:0045664regulation of neuron differentiationNASneuron, neurogenesis (GO term level: 9)10721722 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA14654843 
GO:0005856cytoskeletonNAS10721722 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA2ABC2 | MGC129761ATP-binding cassette, sub-family A (ABC1), member 2-HPRD12421765 
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
CDK5PSSALREcyclin-dependent kinase 5Reconstituted ComplexBioGRID10915792 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)in vitro
in vivo
Reconstituted Complex		BioGRID10915792 |11882646 
-HPRD10721722 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1Two-hybridBioGRID16169070 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
HAP1HAP2 | HIP5 | HLP | hHLP1huntingtin-associated protein 1Two-hybridBioGRID16169070 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5Two-hybridBioGRID16169070 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Two-hybridBioGRID16169070 
MAGEH1APR-1 | APR1 | MAGEHmelanoma antigen family H, 1Two-hybridBioGRID16169070 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinTwo-hybridBioGRID16169070 
SENP2AXAM2 | DKFZp762A2316 | KIAA1331 | SMT3IP2SUMO1/sentrin/SMT3 specific peptidase 2Two-hybridBioGRID16169070 
STARD9DKFZp781J069 | FLJ16106 | FLJ21936 | KIAA1300StAR-related lipid transfer (START) domain containing 9Two-hybridBioGRID16169070 
TBC1D4AS160 | DKFZp779C0666TBC1 domain family, member 4-HPRD12421765 
ZNF259MGC110983 | ZPR1zinc finger protein 259Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 6643All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 5938All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
COLDREN_GEFITINIB_RESISTANCE_UP 8557All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q 11671All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6 5232All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway


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