Gene Page: AXL

Summary
GeneID  558
Symbol  AXL
Synonyms  JTK11|UFO
Description  AXL receptor tyrosine kinase
See related  HGNC:905|MIM:109135|Ensembl:ENSG00000167601|HPRD:00171|
Locus tag  -
Gene type  protein-coding
Map location  19q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)1656220 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS1656220 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS1656220 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AXLJTK11 | UFOAXL receptor tyrosine kinaseAxl forms a homodimer.BIND12470648 
GAS6AXLLG | AXSF | DKFZp666G247 | FLJ34709growth arrest-specific 6-HPRD8621659 
Reconstituted ComplexBioGRID8939948 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Axl interacts with an unspecified isoform of Grb2.BIND12470648 
-HPRD,BioGRID9178760 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9178760 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Axl interacts with an unspecified isoform of Nck2.BIND12470648 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Biochemical ActivityBioGRID9178760 
Axl interacts with an unspecified isoform of p85-alpha.BIND12470648 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Axl interacts with p85-beta.BIND12470648 
-HPRD,BioGRID9178760 
PIK3R3DKFZp686P05226 | FLJ41892 | p55 | p55-GAMMAphosphoinositide-3-kinase, regulatory subunit 3 (gamma)Axl interacts with p55-gamma.BIND12470648 
RANBP9RANBPMRAN binding protein 9Axl interacts with RanBPM.BIND12470648 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1ShcA interacts with Axl.BIND8610109 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Axl interacts with SOCS-1.BIND12470648 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID9178760 
TENC1C1-TEN | C1TEN | DKFZp686D13244 | FLJ16320 | KIAA1075 | TNS2tensin like C1 domain containing phosphatase (tensin 2)-HPRD,BioGRID12470648 
Axl interacts with C1-TEN.BIND12470648 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
NAM_FXYD5_TARGETS_DN 1811All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_UP 2315All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_DN 2418All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_DN 6438All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN 5132All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
COATES_MACROPHAGE_M1_VS_M2_UP 8152All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_DN 2420All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
NAKAMURA_METASTASIS 4728All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_DN 4933All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
ISSAEVA_MLL2_TARGETS 6235All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-24177417801Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-34/44944511A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-913961402m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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