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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PRKD1

Summary

GeneID

5587

Symbol

PRKD1

Synonyms

PKC-MU|PKCM|PKD|PRKCM

Description

protein kinase D1

Locus tag

Gene type

protein-coding

Map location

14q11

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.047

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004700

atypical protein kinase C activity

TAS

8119958

GO:0005515

protein binding

IPI

12893243

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0019992

diacylglycerol binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

TAS

8119958

GO:0007242

intracellular signaling cascade

IEA

GO:0008283

cell proliferation

TAS

8119958

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

TAS

10856238

GO:0005886

plasma membrane

TAS

8119958 |10856238

GO:0005887

integral to plasma membrane

TAS

8119958

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	-	HPRD,BioGRID	12893243
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	AKAP-Lbc interacts with PKD.	BIND	15383279
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD,BioGRID	10561498
C1QBP	GC1QBP \| HABP1 \| SF2p32 \| gC1Q-R \| gC1qR \| p32	complement component 1, q subcomponent binding protein	-	HPRD,BioGRID	10831594
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	PKC-mu interacts with RACK1.	BIND	11884618
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	Affinity Capture-Western	BioGRID	15367659
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	PKC-mu interacts with IGF-IR.	BIND	11884618
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	11948398
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Affinity Capture-Western	BioGRID	11948398
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	Affinity Capture-Western	BioGRID	11948398
MT2A	MT2	metallothionein 2A	-	HPRD,BioGRID	14550308
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	8885868
PLCG2	-	phospholipase C, gamma 2 (phosphatidylinositol-specific)	-	HPRD,BioGRID	8885868
PPP1R14A	CPI-17 \| CPI17 \| PPP1INL	protein phosphatase 1, regulatory (inhibitor) subunit 14A	-	HPRD	15003508
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	PRKCE (PKC-epsilon) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCE from an unspecified species and human PRKD1.	BIND	12223477
PRKCH	MGC26269 \| MGC5363 \| PKC-L \| PKCL \| PRKCL \| nPKC-eta	protein kinase C, eta	PRKCH (PKC-eta) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCH from an unspecified species and human PRKD1.	BIND	12223477
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	PRKD1 (PKC-mu) autophosphorylates.	BIND	12223477
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Affinity Capture-Western	BioGRID	8885868
USP15	KIAA0529 \| MGC131982 \| MGC149838 \| MGC74854 \| UNPH4	ubiquitin specific peptidase 15	PKD phosphorylates USP15.	BIND	16005295
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	10092600 \|10831594
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Reconstituted Complex	BioGRID	12893243

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
ST_GA13_PATHWAY	37	32	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_IGF1_PATHWAY	30	23	All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	31	18	All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM	198	112	All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_METABOLISM	69	40	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN	384	230	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN	120	73	All SZGR genes in this pathway
RICKMAN_METASTASIS_UP	344	180	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_DN	19	14	All SZGR genes in this pathway
YAGI_AML_SURVIVAL	129	87	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP	83	66	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP	295	149	All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP	425	298	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN	44	28	All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN	67	46	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP	207	143	All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN	87	66	All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN	88	68	All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_DN	115	73	All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE	227	151	All SZGR genes in this pathway
DURAND_STROMA_S_UP	297	194	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	618	624	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	618	624	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	27	33	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
				hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
				hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	119	125	1A	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	119	125	1A	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-182	146	152	m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-335	397	403	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-34/449	79	85	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-375	104	110	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-377	180	186	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-431	150	156	1A	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-544	73	79	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.