Gene Page: PSME1

Summary
GeneID  5720
Symbol  PSME1
Synonyms  IFI5111|MGC8628|PA28A|PA28alpha|REGalpha
Description  proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
See related  HGNC:9568|MIM:600654|Ensembl:ENSG00000092010|HPRD:02803|
Locus tag  -
Gene type  protein-coding
Map location  14q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0008538proteasome activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0019884antigen processing and presentation of exogenous antigenIEA-
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP15029244 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000502proteasome complexTAS8811196 
GO:0005829cytosolIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS16130169 
GO:0008537proteasome activator complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3Two-hybridBioGRID16169070 
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6Two-hybridBioGRID16169070 
EMDEDMD | LEMD5 | STAemerinAffinity Capture-Western
Two-hybrid		BioGRID12755701 
PFDN1PDF | PFD1prefoldin subunit 1Two-hybridBioGRID16169070 
PSME1IFI5111 | MGC8628 | PA28A | PA28alpha | REGalphaproteasome (prosome, macropain) activator subunit 1 (PA28 alpha)-HPRD,BioGRID9403698 
PSME2PA28B | PA28beta | REGbetaproteasome (prosome, macropain) activator subunit 2 (PA28 beta)-HPRD,BioGRID8663520 
TUBB2CTUBB2tubulin, beta 2CTwo-hybridBioGRID16169070 
USP22KIAA1063 | USP3Lubiquitin specific peptidase 22Two-hybridBioGRID16169070 
VCLCMD1W | MVCLvinculinTwo-hybridBioGRID16169070 
VIMFLJ36605vimentinTwo-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PROTEASOME 4828All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES 4829All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 5131All SZGR genes in this pathway
REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 4827All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC 4933All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS 5834All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 5631All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 5130All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 8546All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 6536All SZGR genes in this pathway
REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 8450All SZGR genes in this pathway
REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 5331All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 7238All SZGR genes in this pathway
REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 7340All SZGR genes in this pathway
REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 6434All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 5132All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 5230All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
TERAMOTO_OPN_TARGETS_CLUSTER_6 2717All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_G1_G2_UP 129All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP 5240All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
DER_IFN_BETA_RESPONSE_UP 10267All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
GRADE_METASTASIS_DN 4531All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12 7954All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


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