Gene Page: SEMA6A

Summary
GeneID  57556
Symbol  SEMA6A
Synonyms  HT018|KIAA1368|SEMA|SEMA6A1|SEMAQ|VIA
Description  sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
See related  HGNC:10738|MIM:605885|Ensembl:ENSG00000092421|HPRD:06906|
Locus tag  -
Gene type  protein-coding
Map location  5q23.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.144 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005515protein bindingIPI10993894 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceNASaxon (GO term level: 13)10993894 
GO:0007399nervous system developmentNASneurite (GO term level: 5)10993894 
GO:0007010cytoskeleton organizationNAS10993894 
GO:0009887organ morphogenesisNAS10993894 
GO:0007166cell surface receptor linked signal transductionNAS10993894 
GO:0006915apoptosisNAS10993894 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonNASneuron, axon, Neurotransmitter (GO term level: 6)10993894 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS10993894 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EVLRNB6Enah/Vasp-like-HPRD,BioGRID10993894 
SH3RF1FLJ21602 | KIAA1494 | POSH | RNF142 | SH3MD2SH3 domain containing ring finger 1-HPRD12421765 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2-HPRD12421765 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_OTHER_SEMAPHORIN_INTERACTIONS 1514All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_DN 3520All SZGR genes in this pathway
SHI_SPARC_TARGETS_UP 2417All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BHATTACHARYA_EMBRYONIC_STEM_CELL 8960All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 6733All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_UP 9864All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_2_DN 3223All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.113061312m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506130513121A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1285685741Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-132/21230443050m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-141/200a5845911A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-144566572m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1458138201A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497121612221Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-218298304m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-27127312791Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p20382044m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-33139m8hsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-33812101216m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-375205320591Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-377119812041Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-496129413011A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-503121612221Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-77387441Ahsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-9615401546m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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