Gene Page: BARD1

Summary
GeneID  580
Symbol  BARD1
Synonyms  -
Description  BRCA1 associated RING domain 1
See related  HGNC:952|MIM:601593|Ensembl:ENSG00000138376|HPRD:03354|
Locus tag  -
Gene type  protein-coding
Map location  2q34-q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3518 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
USP400.790.82
CAPN20.740.70
SLC44A20.740.70
AK30.720.69
MCCC20.720.69
CHD1L0.720.72
BMP70.720.70
ALDH7A10.720.72
CPT20.710.72
SEPT20.710.74
Top 10 negatively co-expressed genes
IL32-0.40-0.37
FAM159B-0.38-0.26
AF347015.21-0.36-0.18
RP9P-0.32-0.24
TTC9B-0.31-0.28
CLEC3B-0.31-0.36
AL050337.1-0.31-0.13
AC087071.1-0.30-0.13
AL049792.1-0.29-0.15
AC021914.1-0.29-0.10
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingIDA12419249 
GO:0005515protein bindingIPI8944023 |10026184 |10477523 
|15184379 |15265711 
|15782130 
GO:0004842ubiquitin-protein ligase activityNAS15905410 
GO:0008270zinc ion bindingIEA-
GO:0019900kinase bindingNAS15782130 
GO:0042803protein homodimerization activityIPI15265711 
GO:0046872metal ion bindingIEA-
GO:0046982protein heterodimerization activityIPI15265711 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001894tissue homeostasisTAS15782130 
GO:0007050cell cycle arrestNAS15632137 
GO:0006974response to DNA damage stimulusNAS15905410 
GO:0043065positive regulation of apoptosisIMP15782130 
GO:0016567protein ubiquitinationNAS15905410 
GO:0043066negative regulation of apoptosisIMP15265711 
GO:0042325regulation of phosphorylationIMP15782130 
GO:0031441negative regulation of mRNA 3'-end processingNAS15905410 
GO:0045732positive regulation of protein catabolic processNAS15905410 
GO:0046826negative regulation of protein export from nucleusIDA15265711 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000151ubiquitin ligase complexNAS14976165 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA15265711 
GO:0005634nucleusIMP15632137 
GO:0005737cytoplasmIDA15265711 
GO:0031436BRCA1-BARD1 complexIDA15265711 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BARD1-BRCA1 associated RING domain 1Reconstituted ComplexBioGRID11257228 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3-HPRD,BioGRID10362352 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-MS
Affinity Capture-Western
Co-crystal Structure
Co-localization
Co-purification
FRET
Reconstituted Complex
Two-hybrid		BioGRID8944023 |9342365 
|9738006 |9788437 
|10026184 |10477523 
|10635334 |11257228 
|11278247 |11301010 
|11498787 |11504724 
|11526114 |11573085 
|11773071 |11925436 
|11927591 |12431996 
|12438698 |12485996 
|12700228 |12732733 
|12887909 |12890688 
|12951069 |14636569 
|14638690 |14647430 
|15159397 |15184379 
-HPRD8944023 |10026184 
|11573085 |11773071 
|12431996 
-HPRD8944023 |10026184 
|11773071 |12431996 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetCo-purification
Reconstituted Complex		BioGRID14636569 
BRCC3BRCC36 | C6.1A | CXorf53BRCA1/BRCA2-containing complex, subunit 3Affinity Capture-MS
Affinity Capture-Western		BioGRID14636569 
BREBRCC4 | BRCC45brain and reproductive organ-expressed (TNFRSF1A modulator)Affinity Capture-MS
Affinity Capture-Western		BioGRID14636569 
CSTF1CstF-50 | CstFp50cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa-HPRD,BioGRID10477523 |11257228 
CSTF2CstF-64cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDaAffinity Capture-Western
Co-purification		BioGRID10477523 |11257228 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1E2F1 interacts with the BARD1 promoter.BIND11799067 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with the BARD1 promoter region.BIND11799067 
EWSR1EWSEwing sarcoma breakpoint region 1-HPRD,BioGRID12183411 
FANCD2DKFZp762A223 | FA-D2 | FA4 | FACD | FAD | FAD2 | FANCD | FLJ23826Fanconi anemia, complementation group D2Co-localization
Reconstituted Complex		BioGRID12887909 
H2AFXH2A.X | H2A/X | H2AXH2A histone family, member XReconstituted ComplexBioGRID11927591 |12485996 
HIST2H2AB-histone cluster 2, H2abReconstituted ComplexBioGRID11927591 
ING5FLJ23842 | p28ING5inhibitor of growth family, member 5-HPRD15383276 
MED17CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80mediator complex subunit 17Co-purificationBioGRID12154023 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)-HPRD,BioGRID11498787 
MSH3DUP | MGC163306 | MGC163308 | MRP1mutS homolog 3 (E. coli)Reconstituted ComplexBioGRID11498787 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)Reconstituted ComplexBioGRID11498787 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaTwo-hybridBioGRID10362352 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID15184379 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD12154023 
POU2F1OCT1 | OTF1POU class 2 homeobox 1-HPRD11777930 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)Affinity Capture-MS
Affinity Capture-Western		BioGRID14636569 
RBBP8CTIP | RIMretinoblastoma binding protein 8-HPRD,BioGRID10764811 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-WesternBioGRID12700228 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD15383276 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-MS
Affinity Capture-Western		BioGRID14636569 
TP53 (p53) interacts with BARD1.BIND15782130 
UBA1A1S9 | A1S9T | A1ST | AMCX1 | GXP1 | MGC4781 | SMAX2 | UBA1A | UBE1 | UBE1Xubiquitin-like modifier activating enzyme 1Reconstituted ComplexBioGRID11278247 |11927591 
|12431996 |12438698 
|12485996 |12887909 
|15184379 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Reconstituted ComplexBioGRID11278247 |11927591 
|12438698 |12485996 
|12887909 |12890688 
|14636569 |15184379 
UBE2D2E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5Bubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)Reconstituted ComplexBioGRID12431996 
UBE2D3E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5Cubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)-HPRD12732733 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD12732733 
UBE3AANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6Aubiquitin protein ligase E3AReconstituted ComplexBioGRID12890688 
XISTDKFZp779P0129 | DXS1089 | DXS399E | NCRNA00001 | SXI1 | XCE | XIC | swd66X (inactive)-specific transcript (non-protein coding)Co-localizationBioGRID12419249 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6BARD1 interacts with XRCC6 (Ku70).BIND15782130 
ZHX1-zinc fingers and homeoboxes 1-HPRD15383276 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_BARD1_PATHWAY 2919All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP 2113All SZGR genes in this pathway
PYEON_HPV_POSITIVE_TUMORS_UP 9847All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP 14686All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_DN 6241All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN 5325All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_DN 5733All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HBZ 4127All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN 10359All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_DN 1914All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_UP 3825All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_DN 4328All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN 7345All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES 4534All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN 172107All SZGR genes in this pathway
LY_AGING_PREMATURE_DN 3017All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
KANG_DOXORUBICIN_RESISTANCE_UP 5433All SZGR genes in this pathway
SONG_TARGETS_OF_IE86_CMV_PROTEIN 6042All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN 5029All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
CHANG_CYCLING_GENES 14883All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP 4521All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
HAHTOLA_CTCL_CUTANEOUS 2619All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_VINCRISTINE 1910All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G1_S 14776All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway


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